Histological study on the protective effect of endogenous stem-cell mobilization in Adriamycin-induced chronic nephropathy in rats.

Chronic kidney disease is a global health problem with increasing morbidity and mortality. Therefore, this study was planned to test the protective effect of hematopoietic-stem-cell mobilization by granulocyte colony-stimulating factor (G-CSF) on Adriamycin (ADR)-induced chronic renal disease in rats. Thirty albino rats were equally divided into three groups: control, ADR group [rats received a single intravenous injection of ADR (5 mg/kg)], and G-CSF group [rats received ADR by the same route and the same dose as the previous group, and then G-CSF (70 μg/kg/d) 2 hours after ADR injection then daily for five consecutive days].

Effect of bone marrow derived mesenchymal stem cells on healing of induced full-thickness skin wounds in albino rat.

Background And Objectives: Mesenchymal stem cells have delivered new approaches to the management of wound healing in severe skin injuries. This work was planned to evaluate the effect of bone marrow-derived mesenchymal stem cells (BMSCs) on healing of induced full thickness skin wounds in albino rats using topical & systemic injections.

Methods And Results: Forty adult male albino rats were classified into 2 groups after induction of full thickness skin wound; untreated group and stem cell-treated group.