Publications by authors named "Nagisa Oi"
Article Synopsis
- Polycystic ovary syndrome (PCOS) is linked to elevated androgens, which cause endoplasmic reticulum (ER) stress in granulosa cells and lead to the buildup of harmful substances called advanced glycation end products (AGEs).
- The study shows that testosterone increases the expression of a receptor for AGEs (RAGE) and the accumulation of AGEs in human granulosa-lutein cells, with the process being reduced by an ER stress inhibitor called tauroursodeoxycholic acid (TUDCA).
- Targeting the AGE-RAGE pathway, using either a RAGE inhibitor or TUDCA, may offer new therapeutic options for managing PCOS by reducing RAGE expression and improving ovarian
Aim: The cryopreservation of embryos is essential for assisted reproductive technology field. The aim of the present study is to examine the efficacy and ease of use of a new vitrification device, Kitasato Vitrification System (KVS), in cryopreservation of human embryos.
Methods: Human embryos at the cleavage or blastocyst stage were vitrified and warmed by KVS or Cryotop (control device).
Article Synopsis
- Endometriosis negatively impacts ovarian health by increasing apoptosis and oxidative stress in granulosa cells, key components for follicle development.
- The study suggests that endoplasmic reticulum (ER) stress is heightened in granulosa cells from women with endometriosis, which is linked to oxidative stress and is regulated by specific stress response proteins.
- Treatment with H2O2 exacerbates apoptosis in these cells, whereas tauroursodeoxycholic acid (TUDCA), an ER stress inhibitor, can reduce this apoptosis, indicating potential therapeutic targets for improving ovarian function in endometriosis patients.
Aim: The objective of this study is to determine the factors associated with successful pregnancy in women of late reproductive age with uterine fibroids who undergo embryo cryopreservation before surgery (ECBS).
Methods: Patients who underwent in vitro fertilization treatment with controlled ovarian stimulation from November 2010 to January 2017 in our university hospital were included. Twenty-two patients older than 35 years of age at the first visit with cavity-distorting uterine fibroids underwent ECBS, a three-step therapeutic approach consisting of oocyte pick-up, myomectomy and embryo transfer (ET), which are performed in this order.
Although assisted reproductive technology (ART) is suspected to increase the risk of placenta previa, a life-threatening complication of pregnancy, the reason is poorly understood. We recruited consecutive 318 pregnancies conceived by ART in our clinic and examined relation of ten variables, i.e.
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