[Structure-functional status of the erythrocyte membrane in acute poisoning by metaphos and administration of perftoran].

The effect of perftoran administration on structure-functional state of erythrocyte membrane was investigated under conditions of metaphos intoxication. Metaphos administration at the dose of LD50 caused pronounced membrane-toxic effect. Perphtoran administration to animals reduced manifestation of the membrane damage.

[Importance of some apudocytes in gastric ulcer bleeding prediction].

In 6 patients with uncomplicated gastric ulcer (GU) and 8 patients with GU complicated by acute bleeding morphohistochemical and ultrastructural analysis of apudocytes of gastric mucous membrane in the ulcer, periulcer and remote zone was carried out with detection of morphofunctional changes predicting ulcer bleeding. It is established that G- and ECL-apudocytes hyperplasia and hyperfunction in these zones have stable, irreversible nature in gastric ulcer bleeding, and are reliable prognostic criteria of this complication.

[Effect of ionizing radiation and physical loads on pyrimidine-5'-nucleotidase activity in rat liver subcellular fractions].

Activity of pyridine-5'-nucleotidase in the mitochondria and postmitochondrial supernatant of the rat liver has been studied as affected by the radiation and physical load (running till tiredness). It is shown that physical load leads to double increase of cytidinemonophosphatase activity and does not actually affect uridine monophosphate one. Irradiation evokes changes of cytidine monophosphatase activity of the studied fractions in time: 1 year after irradiation it increases by 45%, 1 day later it sharply changes and 3 days later it increases again.

[The effect of ionizing radiation and physical loading on the molecular heterogeneity of nucleoside phosphate kinases in liver subcellular fractions].

The different molecular forms of nucleoside-monophosphate kinases (KF 2.7.4.

[Activity of alanine- and aspartate-aminotransferases in organs of albino rats subjected to whole body gamma-irradiation and physical exercise].

The investigations of enzyme activity such as aspartate aminotransferase (AST, KE 2.6.1.

[Effect of pyridoxal phosphate on the activity of aminotransferases in different structure-functional regions of the rabbit brain in radiation sickness].

Pyridoxal enzymes of transamination (aspartate aminotransferase, KF 2.6.1.

[Effect of pyridoxal phosphate on gamma-aminobutyric acid metabolism in different sections of the brain in irradiated animals].

A study was made of the effect of X-rays (4,5 Gy) and pyridoxal phosphate (3 mg/kg, v/v) on the activity of pyridoxal enzymes of GABA metabolism (e.g. glutamate decarboxylase, E.

[Pyridoxal phosphate as an agent for normalizing the monoamine oxidase activity of the brain in radiation sickness].

A study was made of the influence of the coenzyme pyridoxal phosphate on the activity of mitochondrial monoaminoxidase (MAO) catalyzing oxidative deamination of serotonin at the exacerbation of acute radiation disease (on the 6th day after radiation exposure) in different parts of the brain (cerebral hemisphere, stem and cerebellum). Experiments were staged on rabbits, irradiated by x-ray at a dose of 4.5 Gy with a dose rate of 0.

[Monoamine oxidase activity in gastrointestinal tract tissues of animals after irradiation and administration of pyridoxal phosphate].

The X-ray irradiation in a dose of 450 R is shown to decrease the monoaminoxidase activity in the cell fractions of the mucous membrane of small intestine as against the fractions of the stomach mucosa. The administration of pyridoxalphosphate to the irradiated rabbits increases the monoaminoxidase activity in the fraction and subfractions of small intestine mucosa mitochondria, but the enzyme activity being compared with the control group has a tendency to decrease.

[Changes in the level of pyrimidine nucleoside phosphates in the liver of irradiated rats].

Content of uridyl and cytidyl nucleoside-phosphates in the liver of rats irradiated by gamma-rays (60Co) in a dose of 774 mC/kg (3000 P) was studied 0.5, 1, 3, 6 and 24 h after the effect. A trustworthy decrease of UTP and CTP as well as UDP and CDP content 24 h after irradiation was found.

[Catabolism of pyrimidine nucleotides in the liver of irradiated animals].

A study was made of the activity of nucleoside diphosphatase (NDPase, EC 3.6.1.

[Nucleoside mono- and nucleoside diphosphate kinase activities in rat liver and brain in radiation sickness].

Activity of nucleoside di- and nucleoside triphosphates metabolism enzymes in tissues of rats gamma-irradiated by a dose of 30 Gy was studied 0.5, 1, 3, 6 and 24 hours after the radiation effect. It is shown that the nucleoside monophosphate kinase activity of the liver and brain is enhanced almost at all stages of the studies and the nucleoside diphosphate kinase activity is inhibited.

[Early changes in the nucleoside diphosphate kinase activity of the rat brain and liver during whole body gamma irradiation in an absolutely lethal dose].

Nucleoside diphosphatkinase activity in mitochondria and post-mitochondrial supernatant fraction from brain and liver tissues was shown to decrease sharply during the first 60 min after total-body gamma-irradiation of rats with an absolutely lethal dose (30 Gy). A significant increase in the enzyme activity was registered 3 and 24 h following irradiation. Changes in nucleoside diphosphatkinase activity were more pronounced in mitochondria (particularly in liver mitochondria) than in the supernatant fraction.