Publications by authors named "Nagi Katano"
Article Synopsis
- - Immune checkpoint inhibitors are important for boosting anticancer immunity, but their effectiveness is limited by low response rates and side effects.
- - This study investigates progesterone (P4) for its potential anticancer properties, specifically its ability to improve immune regulation without the negative impacts seen with cortisol.
- - Researchers developed a liposome-encapsulated P4 combined with an anti-PD-L1 antibody, which showed promise in reducing tumor growth and inflammation while promoting a healthier immune response in cancer models.
Progesterone (P4) and glucocorticoid (GC) play crucial roles in the immunoregulation of a mother to accept and maintain a semi-allogenic fetus. P4 concentration increases during pregnancy and becomes much higher in the placenta than in the other peripheral tissues, wherein the concentration of cortisol (COR), the most abundant GC and a strong immunosuppressor, remains uniform throughout the rest of the body. Here, we evaluated the effect of a high-P4 environment on pregnant immunity by comparing it with COR.
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