Publications by authors named "Naghmeh Asadimanesh"
Acute Lymphoblastic Leukemia (ALL) is a heterogeneous blood cancer characterized by the uncontrolled growth of immature lymphoid cells due to dysregulated signaling pathways. It is the most common pediatric cancer, with high cure rates in children, but significantly lower survival rates in adults. Current theranostic strategies, including chemotherapy, immunotherapy, and nanomedicine, aim to improve detection and treatment precision but are limited by side effects, drug resistance, high costs, and stability issues.
View Article and Find Full Text PDFBackground: This study investigated the association of atorvastatin use on survival, need for intensive care unit (ICU) admission, and length of hospital stay (LOS) among COVID-19 inpatients.
Materials And Methods: A retrospective study was conducted between March 20th, 2020, and March 18th, 2021, on patients with confirmed COVID-19 admitted to three hospitals in Tehran, Iran. The unadjusted and adjusted effects of atorvastatin on COVID-19 prognosis were investigated.
Background: Coronavirus infection can induce the production of inflammatory cytokines leading to acute respiratory distress syndrome (ARDS) and death. It is well-established that interferons (IFNs) are essential in regulating the immune response, thus their effects of IFNs on COVID-19 patients should be subject to investigation. This study aimed to investigate the effects of IFN-α alone or in combination with remdesivir in hospitalized COVID-19 patients.
View Article and Find Full Text PDFMacrophages are types of immune cells, with ambivalent functions in tumor growth, which depend on the specific environment in which they reside. Tumor-associated macrophages (TAMs) are a diverse population of immunosuppressive myeloid cells that play significant roles in several malignancies. TAM infiltration in malignancies has been linked to a poor prognosis and limited response to treatments, including those using checkpoint inhibitors.
View Article and Find Full Text PDFArticle Synopsis
- The study focused on understanding the demographics and clinical data of COVID-19 patients in Iran, especially their relationship with death rates and case fatality rates (CFR) from March 2020 to March 2021.
- Out of 5,318 patients analyzed, the median age was 60, with prevalent comorbidities like hypertension and diabetes, and common symptoms including cough, dyspnea, and fever identified.
- Key predictors of death from COVID-19 included factors like older age, lowered consciousness, high comorbidity count, and ICU admissions, indicating the importance of identifying these predictors to improve patient care and outcomes.