Clinically Advancing BDK Inhibitors.

The physiopathology of cardiac and related disorders is strongly associated with BCAA metabolic imbalance. BDK, a negative regulator of the BCKDH complex, is significant in BCAA catabolic dysfunction. A Clinically potential BDK inhibitor, PF-07328948, with excellent drug-like properties, is under phase-1 clinical trials for CVD metabolic disorders.

Fabrication of hafnium-based nanoparticles and nanostructures using picosecond laser ablation.

This work presents a unique and straightforward method to synthesise hafnium oxide (HfO) and hafnium carbide (HfC) nanoparticles (NPs) and to fabricate hafnium nanostructures (NSs) on a Hf surface. Ultrafast picosecond laser ablation of the Hf metal target was performed in three different liquid media, namely, deionised water (DW), toluene, and anisole, to fabricate HfO and HfC NPs along with Hf NSs. Spherical HfO NPs and nanofibres were formed when Hf was ablated in DW.

Multi-objective optimization for minimize cutting force and power consumption in corn stalk chopping processes.

This study was on optimization of the cutting processes for corn stalks, which serve as significant sources of biomass and forage. The reduction of cutting force is crucial for enhancing energy efficiency. Cutting velocity rises, which can lead to significant power usage with minimal shear forces.

Sub-70 nm surface structures on femtosecond laser irradiated GaAs in distilled water and sensing application.

This study reveals the possibility of distinct ablation mechanisms at different radial positions of the ablated track on GaAs when ablated with femtosecond pulses in distilled water. From the center to the edges of the ablated track, fascinating features such as micron-sized cones, nano-pores, and nano-ripple trenches (average size of 60-70 nm) were observed. The requirement for simulations incorporating the variations in a Gaussian beam fluence and dynamics of the melt flow/surrounding media is discussed.

Driving errors as a function of listening to music and FM radio: A simulator study.

Objectives: Driving is a dynamic activity that takes place in a constantly changing environment, carrying safety implications not only for the driver but also for other road users. Despite the potentially life-threatening consequences of incorrect driving behavior, drivers often engage in activities unrelated to driving. This study aims to investigate the frequency and types of errors committed by drivers when they are distracted compared to when they are not distracted.

Two-mode squeezing over deployed fiber coexisting with conventional communications.

Squeezed light is a crucial resource for continuous-variable (CV) quantum information science. Distributed multi-mode squeezing is critical for enabling CV quantum networks and distributed quantum sensing. To date, multi-mode squeezing measured by homodyne detection has been limited to single-room experiments without coexisting classical signals, i.

Studies on Evaluation of the Thermal Conductivity of Alumina Titania Hybrid Suspension Nanofluids for Enhanced Heat Transfer Applications.

Extensive investigations were made and empirical relations were proposed for the thermal conductivity of mono-nanofluids. The effect of concentration, diameter, and thermal properties of participating nanoparticles is missing in the majority of existing thermal conductivity models. An attempt is made to propose a model that considers the influence of such missing parameters on the thermal conductivity of hybrid nanofluids.

Precipitation is the main axis of tropical plant phylogenetic turnover across space and time.

Early natural historians-Comte de Buffon, von Humboldt, and De Candolle-established environment and geography as two principal axes determining the distribution of groups of organisms, laying the foundations for biogeography over the subsequent 200 years, yet the relative importance of these two axes remains unresolved. Leveraging phylogenomic and global species distribution data for Mimosoid legumes, a pantropical plant clade of c. 3500 species, we show that the water availability gradient from deserts to rain forests dictates turnover of lineages within continents across the tropics.

A novel and efficient one-pot strategy for the synthesis of 1,2,4-triazoles: access to synthesis of penipanoid A and its analogues.

We developed a novel one-pot strategy for synthesizing biologically important 1,2,4-triazole motifs from easily accessible 4-hydroxy phenylacetic acid, formamidine hydrochloride and hydrazine derivatives under mild conditions. This strategy enabled us to synthesize the natural penipanoid A and its analogues in one step.

Physiochemical characterization of sodium doped zinc oxide nano powder for antimicrobial applications.

Zinc oxide (ZnO) is one of the semiconductor materials with unique antimicrobial properties towards various microorganisms. In this article, pure and Na doped ZnO nanopowders were synthesized by easiest and cost-effective co-precipitation process. X-ray diffraction (XRD),Fourier transform infrared spectroscopy(FT-IR), ultraviolet - visible (UV - Vis) spectroscopy, scanning electron microscopy(SEM), and Energy dispersive X-ray analysis (EDAX) techniques were used to characterize the particle size, surface morphology and chemical composition of prepared materials.

Optimal resource allocation for flexible-grid entanglement distribution networks.

We use a genetic algorithm (GA) as a design aid for determining the optimal provisioning of entangled photon spectrum in flex-grid quantum networks with arbitrary numbers of channels and users. After introducing a general model for entanglement distribution based on frequency-polarization hyperentangled biphotons, we derive upper bounds on fidelity and entangled bit rate for networks comprising one-to-one user connections. Simple conditions based on user detector quality and link efficiencies are found that determine whether entanglement is possible.

Deep Transfer Learning for Automatic Prediction of Hemorrhagic Stroke on CT Images.

Intracerebral hemorrhage (ICH) is the most common type of hemorrhagic stroke which occurs due to ruptures of weakened blood vessel in brain tissue. It is a serious medical emergency issues that needs immediate treatment. Large numbers of noncontrast-computed tomography (NCCT) brain images are analyzed manually by radiologists to diagnose the hemorrhagic stroke, which is a difficult and time-consuming process.

Bioconversion of chitin waste through Stenotrophomonas maltophilia for production of chitin derivatives as a Seabass enrichment diet.

Marine wastes pose a great threat to the ecosystem leading to severe environmental hazards and health issues particularly the shellfish wastes. The shellfish waste which contains half of the amount of chitin can be efficiently transformed into useful products. Various approaches for the hydrolysis of chitin like physical, chemical, and enzymatic processes are there.

Influence of extracellular protein isolated from fish gut associated bacteria as an enhancer of growth and innate immune system in Mugil cephalus.

The cultural microbiomes of 27 bacteria colonies were isolated from Mugil cephalus for analysis of the antibacterial and antagonistic activities. A potent probiotic bacterium was characterized using16S r RNA sequencing. The potent strain was added to fish diet to perform the challenge test and to study the growth and immunological parameter.

Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance.

Third generation Hepatitis C virus (HCV) NS3/4A protease inhibitors (PIs), glecaprevir and voxilaprevir, are highly effective across genotypes and against many resistant variants. Unlike earlier PIs, these compounds have fluorine substitutions on the P2-P4 macrocycle and P1 moieties. Fluorination has long been used in medicinal chemistry as a strategy to improve physicochemical properties and potency.

Characterization of bacterial community in oil-contaminated soil and its biodegradation efficiency of high molecular weight (>C40) hydrocarbon.

In this study, two biosurfactant producing Pseudomonas aeruginosa sp. were isolated from motor oil contaminated soil for crude oil, alkane and PAH degradation studies. Metagenomics analysis identified as proteobacteria phyla was the dominant.

Trace level detection of explosives and pesticides using robust, low-cost, free-standing silver nanoparticles decorated porous silicon.

We report results from our extensive studies on the fabrication of ultra-thin, flexible, and cost-effective Ag nanoparticle (NP) coated free-standing porous silicon (FS-pSi) for superior molecular sensing. The FS-pSi has been prepared by adopting a simple wet-etching method. The deposition time of AgNO has been increased to improve the number of hot-spot regions, thereby the sensing abilities are improved efficiently.

Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.

The three pan-genotypic HCV NS3/4A protease inhibitors (PIs) currently in clinical use-grazoprevir, glecaprevir, and voxilaprevir-are quinoxaline-based P2-P4 macrocycles and thus exhibit similar resistance profiles. Using our quinoxaline-based P1-P3 macrocyclic lead compounds as an alternative chemical scaffold, we explored structure-activity relationships (SARs) at the P2 and P4 positions to develop pan-genotypic PIs that avoid drug resistance. A structure-guided strategy was used to design and synthesize two series of compounds with different P2 quinoxalines in combination with diverse P4 groups of varying sizes and shapes, with and without fluorine substitutions.

Perceptions of the Health Care Workers about the Guideline Implemented for Safe Surgical Practice during COVID-19 Pandemic in a University Teaching Hospital.

One area of health care delivery that has been affected badly in most of the institutions is the running of the surgical services. This is due to various factors such as the presence of asymptomatic carrier stage, increased morbidity and mortality in surgical procedures in a COVID-19 patient, and possible transmission of disease to the health care workers (HCWs). A guideline was formulated in our institution, which is a tertiary care university teaching hospital to resume the surgical activities in full.

Nasal vestibule and columella cancer: a therapeutic and reconstructive conundrum.

Purpose Of Review: Nasal vestibular cancers are rare entities among the head and neck cancers. The treatment options are varied. Although surgical treatment plays an important role, postablative defects are difficult to reconstruct.

Ag[Fe(CN)NO]-Fabricated Hydrophobic Cotton as a Potential Wound Healing Dressing: An Approach.

There have been reports of different types of wound dressings for various functions and purposes. Cotton being one of the most widely used wound dressing material due to its non-toxic, biodegradable, and other properties is used for fabrication as well as in the form of scaffolds for faster and effective wound closure. Our research team has already demonstrated the role of silver nitroprusside nanoparticles (SNPNPs) for wound healing and antibacterial activity.