Ecosystem-scale insights into the dynamics of dissolved organic matter in an Asia's largest brackish water lagoon: Sources, fluxes, and biogeochemical significance.

A twenty-four month long observational study conducted in an Asia's largest brackish water ecosystem, Chilika Lagoon, India, aimed to unravel dissolved organic matter (DOM) dynamics in this tropical brackish water ecosystem. The study assessed the interplay between allochthonous and autochthonous DOM sources during lean and active flow periods based on regional rainfall. Dissolved organic carbon (DOC), nitrogen (DON), and phosphorus (DOP) fluxes were analyzed, considering catchment runoff, phytoplankton production, benthic-pelagic interactions, and sea-lagoon exchanges as contributors.

Assessment of heavy metal distribution in seawater of Kakinada Bay, a tropical mangrove-rich coastal environment.

The main objective of the present study is to estimate the heavy metal concentrations and ecological risk index (ERI) in the seawater of Kakinada Bay. Turbidity, suspended particulate matter (SPM), pH, salinity, dissolved oxygen, along with heavy metals were recorded from twelve locations of the Bay to understand its hydrographical conditions. The distribution of environmental variables and heavy metal concentrations was noticed mostly from the south to north gradient.

Quantification and In Silico Toxicity Assessment of Nimesulide and its Related Substances.

Availability of analytical method which is compatible with both Ultra high performance liquid chromatography (UHPLC) and Liquid chromatography mass spectrometry to identify and quantify the impurities in pharmaceutical products is an advantage for drug product development; such analytical method was developed for Nimesulide using a fused core column. Ammonium acetate and methanol were used as mobile phase in the gradient elution at a detection wavelength 230 nm. Quality-by-design principles helped in identifying the critical method development parameters and design space.