Publications by authors named "Nagendrababu Jarapala"
Hyperuricemia remains the most prevalent cause of gout. Gout patients present with joint inflammation and uric acid crystals deposition manifesting as tophi. The association of gout with increased risk of insulin resistance, diabetes, metabolic disorders, increased cardiometabolic risk, and kidney disease is well established.
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- Polycystic ovary syndrome (PCOS) is a common hormonal disorder in premenopausal women, characterized by irregular menstruation, ovulation issues, and excess androgen levels, often linked with insulin resistance and various metabolic disorders.
- Current treatments like metformin show limited effectiveness, highlighting the need for new therapies.
- Novel antidiabetic drugs, such as sodium-glucose co-transporter 2 inhibitors and glucagon-like peptide-1 receptor agonists, may offer benefits for PCOS patients by improving weight loss, insulin resistance, and cardiovascular health, but more research is needed on their safety and efficacy in this context.
Bile cast nephropathy (BCN) or cholemic nephropathy (CN) is an acute renal dysfunction, including acute kidney injury (AKI) in the setting of liver injury. It is a common phenomenon in patients with liver disease and is associated with significant morbidity and mortality. CN is characterized by hemodynamic changes in the liver, kidney, systemic circulation, intratubular cast formation, and tubular epithelial cell injury.
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