Interaction of cancer cells with magnetic nanoparticles modified by methacrylamido-folic acid.

Background: Magnetic nanoparticles show great promise for use as tools in a wide variety of biomedical applications. The purpose of this study was to investigate the potential effects of methacrylamido-folic acid (Ma-Fol)-modified magnetic nanoparticles on 5RP7 (H-ras-transformed rat embryonic fibroblasts) and NIH/3T3 (normal mouse embryonic fibroblasts).

Methods: The cytotoxicity and viability of 5RP7 and NIH/3T3 cells were detected.