Synthesis and characterization of chitosan silver nanoparticle decorated with benzodioxane coupled piperazine as an effective anti-biofilm agent against MRSA: A validation of molecular docking and dynamics.

Biomaterial research has improved the delivery and efficacy of drugs over a wide range of pharmaceutical applications. The objective of this study was to synthesize benzodioxane coupled piperazine decorated chitosan silver nanoparticle (Bcp*C@AgNPs) against methicillin-resistant Staphylococcus aureus (MRSA) and to assess the nanoparticle as an effective candidate for antibacterial and anti-biofilm care. Antibacterial activity of the compound was examined and minimum inhibitory concentration (MIC) was observed at (10.

Development of piperazine-1-carbothioamide chitosan silver nanoparticles (P1C-Tit*CAgNPs) as a promising anti-inflammatory candidate: a molecular docking validation.

Natural products are important leads in drug discovery. The search for effective plant-derived agents or their synthetic analogues has continued to be of interest to biologists and chemists for a long time. Herein, we have synthesized a novel compound, P1C, and P1C-Tit*CAgNPs from chitosan; P1C is a precursor and an anti-inflammatory candidate, which has been validated by molecular docking studies.

Anti-hypercholesterolemic influence of the spice cardamom (Elettaria cardamomum) in experimental rats.

Background: Cardamom (Elettaria cardamomum) is an aromatic seed spice grown extensively in India and used as a flavoring in sweets. In this study, the anti-hypercholesterolemic effect of cardamom was evaluated in Wistar rats by inducing hypercholesterolemia with a high-cholesterol diet for 8 weeks. Dietary interventions were made with (a) cardamom powder (50 g kg ), (b) cardamom oil (3 g kg , equivalent to 50 g kg cardamom) and (c) de-oiled cardamom powder (50 g kg ).

An investigation of social judgments made by young adults toward appearance of dental fluorosis.

Background: Smile is a crucial factor in creating a good first impression. However conditions like dental fluorosis hamper the esthetics of teeth. This study was conducted to find out whether young adults attribute socially relevant characteristics to people with dental fluorosis.

Ni(NO3)2·6H2O/I2/water: A new, mild and efficient system for the selective oxidation of alcohols into aldehydes and ketones under sonic condition.

A new, simple, efficient and rapid method for the oxidation of alcohols into respective aldehydes and ketones by Ni(NO(3))(2)·6H(2)O/I(2)/water system under ultrasonic irradiation is reported. The process is mild and inexpensive; the yields are high and the reactions go to completion within 2-7min.

Red cell distribution width in the diagnosis of iron deficiency anemia.

Objective: 1. To compare peripheral smear (PS) and Red cell distribution width (RDW) in diagnosis of Iron deficiency anemia (IDA) in various grades. 2.

Menetrier's disease.

An 8-year-old girl presented with persistent vomiting, pain abdomen and generalized edema. Barium studies and gastroscopy suggested hypertrophic gastropathy. Histopathological examination pointed the diagnosis towards Menetrier's Disease.