An early Indian experience with benralizumab - A compendium on severe asthma cases: a case series.

Severe eosinophilic asthma (SEA), one of the phenotypes of asthma that is characterized by elevated blood eosinophil counts, is a common cause of uncontrolled asthma. Patients with SEA often experience severe persistent symptoms and have frequent exacerbations despite optimal inhaler therapy. They also have poor lung function and quality of life (QoL).

A Comparative Study of the Safety and Efficacy of Intrapleural Fibrinolysis With Streptokinase and Urokinase in the Management of Loculated Pleural Effusions.

Background Intrapleural fibrinolytic therapy (IPFT) with streptokinase (STK), urokinase (UK), and alteplase remains a common practice for managing loculated pleural effusions (LPEs). However, very limited data are available on the comparative efficacy of these agents. Methodology We compared the efficacy and safety of intrapleural streptokinase (n = 28) and urokinase (n = 38) in 66 patients with loculated effusions.

Bronchial thermoplasty for severe asthma: A position statement of the Indian chest society.

Unlabelled: Bronchial thermoplasty (BT) is an interventional bronchoscopic treatment for severe asthma. There is a need to define patient selection criteria to guide clinicians in offering the appropriate treatment options to patients with severe asthma.

Methodology: An expert group formed this statement under the aegis of the Indian Chest Society.

First-line management of metastatic non-small cell lung cancer: An Indian perspective.

Lung cancer has been the most common cancer in the world for several decades. The non-small cell lung cancer (NSCLC) constitutes approximately about 80% of the total cases of lung cancer. Therapeutic interventions in NSCLC have shifted to the target-based approach from histology-based approach, and this has completely changed the face of the management of NSCLC.

Splenic and lymph nodal involvement in sarcoidosis mimicking lymphoma on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography.

Sarcoidosis is a multisystemic disease presenting with well-defined, bilateral, symmetric hilar and right paratracheal lymph node enlargement. Recently, fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) has been used to stage and detect occult site of active inflammation in sarcoidosis. F-18 FDG PET/CT has become a cornerstone imaging modality in the modern lymphoma management, which can present with generalized lymphadenopathy including mediastinal.

Ocular sarcoidosis: does (18)F-FDG PET/CT have any role?

Sarcoidosis is a multisystemic disease, which may affect almost any organ including the eyes. Recently, F-FDG PET/CT has proved to be a very useful molecular imaging method allowing to obtain a complete morphofunctional cartography of active inflammatory sites and to assess treatment response in patients with sarcoidosis. We report 2 cases of sarcoidosis where F-FDG PET/CT showed intense FDG uptake in the eye globes along with multiple enlarged mediastinal lymph nodes suggestive of active sarcoidosis with ocular involvement.

Serum Paraoxonase (PON1) Activity in North-West Indian Punjabi's with Acute Myocardial Infarction.

Human serum paraoxonase-1 (PON1), an enzyme on HDL prevents oxidation of LDL thereby preventing the development of atherosclerosis. Studies done so far have lead to conflicting results. As studies are lacking in North-West Indian Punjabi's, a distinct ethnic group with high incidence of coronary artery disease, we determined PONase activity in this population.

Low serum PON1 activity: an independent risk factor for coronary artery disease in North-West Indian type 2 diabetics.

The paraoxonase (PON1) gene polymorphisms are known to affect the PON1 activity and coronary artery disease (CAD) risk. Studies done so far have given conflicting results. In the present study, we determined the role of PON1 genetic variants and PON1 activity in the development of CAD in North-West Indian Punjabis, a distinct ethnic group, having high incidence of both CAD and type 2 diabetes.

Paraoxonase 1 (PON1) polymorphisms, haplotypes and activity in predicting cad risk in North-West Indian Punjabis.

Background: Human serum paraoxonase-1 (PON1) prevents oxidation of low density lipoprotein cholesterol (LDL-C) and hydrolyzes the oxidized form, therefore preventing the development of atherosclerosis. The polymorphisms of PON1 gene are known to affect the PON1 activity and thereby coronary artery disease (CAD) risk. As studies are lacking in North-West Indian Punjabi's, a distinct ethnic group with high incidence of CAD, we determined PON1 activity, genotypes and haplotypes in this population and correlated them with the risk of CAD.

Role of gastric bypass in patients with unresectable advanced carcinoma of stomach.

Context: Role of bypass as a palliative surgery for advanced gastric cancer remains controversial.

Aims: To determine the role of bypass in advanced gastric cancer in comparision to resection as gold standard.

Design: Hospital-based retrospective outcome as study.

Role of gastric bypass in patients with unresectable advanced carcinoma of stomach.

Context: Role of bypass as a palliative surgery for advanced gastric cancer remains controversial.

Aims: To determine the role of bypass in advanced gastric cancer in comparision to resection as gold standard.

Design: Hospital based retrospective outcome study

Methods: Patients were divided into three groups: group I (gastric resection), group II (bypass) and group III (exploratory laparotomy alone).