Polypyrrole functionalized MoS for sensitive and simultaneous determination of heavy metal ions in water.

Assessing heavy metal ion (HMI) contamination to sustain drinking water hygiene is a challenge. Conventional approaches are appealing for the detection of HMIs but electrochemical approaches can resolve the limitations of these approaches, such as tedious sample preparation, high cost, time consuming and the need for trained professionals. Here, an electrochemical approach is developed using a nano-sphered polypyrrole (PPy) functionalized with MoS (PPy/MoS) by square wave anodic stripping voltammetry for the detection of HMIs.

Engineering the Coordination Environment in the Silver(I)- and Ruthenium(II)--Heterocyclic Carbene Complexes in Instigating the Electrocatalytic Hydrogen Evolution Reaction.

The quest for cost-efficient and high-performance electrocatalysts towards electrocatalytic water splitting is a key and an interdisciplinary area of study. Considerable progress is being driven by developments in the field of energy research. In a fundamental study, we have synthesized NHC precursors ( and ) and corresponding metal-NHC complexes of silver(I)- ( and ) and ruthenium(II)- ( and ) of a N-heterocyclic carbene-based ligand type incorporating coumarins.

Influence of building orientation and thermal mass configuration on the prediction of Natural Ventilation Potential (NVP) of various climates of India.

Natural ventilation potential (NVP) of a climate is a theoretical basis, and it gains importance due to the promising need for building energy conservation while conceding required thermal comfort conditions. A modified NVP analytical model is proposed by considering parameters involved in the earlier models (Yang et al., Build Environ 40:738-746, 2005; Luo et al.

A Simple Nickel Metal-Organic Framework-Catalyzed Borylation of Aryl Chlorides and Bromides.

We report a recyclable and efficient catalyst system based on a nickel-benzene tricarboxylic acid metal-organic framework (Ni-BTC MOF) for the borylation of aryl halides, including aryl chlorides, with (pinacolato)diboron, affording aryl boronate esters in high yields (up to >99% yield) with high selectivity. This protocol demonstrates broad functional group tolerance. Catalyst can be recyclable up to four times, and gram-scale reactions further highlights the usefulness of this method.

Synthesis of Alkyl and Aryl Boronate Esters via CeO-Catalyzed Borylation of Alkyl and Aryl Electrophiles Including Alkyl Chlorides.

A recyclable protocol using a CeO-nanorod catalyst for borylation of alkyl halides with Bpin (pin = OCMeCMeO) is reported. A wide range of synthetically useful alkyl boronate esters are readily obtained from primary and secondary alkyl electrophiles, including unactivated alkyl chlorides, demonstrating broad utility and functional group tolerance. Preliminary investigation revealed an involvement of in situ formed catalytically active boryl species.

Tuning the Surface Functionality of FeO for Sensitive and Selective Detection of Heavy Metal Ions.

The functionalization of materials for ultrasensitive detection of heavy metal ions (HMIs) in the environment is crucial. Herewith, we have functionalized inexpensive and environmentally friendly FeO nanoparticles with D-valine (FeO-D-Val) by a simple co-precipitation synthetic approach characterized by XRD, FE-SEM, and FTIR spectroscopy. The FeO-D-Val sensor was used for the ultrasensitive detection of Cd, Pb, and Cu in water samples.

Balancing Clinician Workload Through Strategic Patient Panel Designs.

Background And Objectives: Clinician workload is a key contributor to burnout and well-being as well as overtime and staff shortages, particularly in the primary care setting. Appointment volume is primarily driven by the size of patient panels assigned to clinicians. Thus, finding the most appropriate panel size for each clinician is essential to optimization of patient care.

Recent advances in the chemistry of the phosphaethynolate and arsaethynolate anions.

Over the past decade, the reactivity of 2-phosphaethynolate (OCP), a heavier analogue of the cyanate anion, has been the subject of momentous interest in the field of modern organometallic chemistry. It is used as a precursor to novel phosphorus-containing heterocycles and as a ligand in decarbonylative processes, serving as a synthetic equivalent of a phosphinidene derivative. This perspective aims to describe advances in the reactivities of phosphaethynolate and arsaethynolate anions (OCE; E = P, As) with main-group element, transition metal, and f-block metal scaffolds.

Prolonged post-ictal atrial fibrillation following seizures.

It is well known that several types of cardiac arrhythmias can occur after a seizure, with ictal sinus tachycardia being the most common. However, post-ictal atrial fibrillation (PIAF) is a rare phenomenon with significant clinical implications. We describe the case of an epilepsy patient with prolonged PIAF.

Clinician Care Team Composition and Health Care Utilization.

Objective: To test the hypothesis that a greater proportion of physician time on primary care teams are associated with decreased emergency department (ED) visits, hospital admissions, and readmissions, and to determine clinician and care team characteristics associated with greater utilization.

Patients And Methods: We retrospectively analyzed administrative data collected from January 1 to December 31, 2017, of 420 family medicine clinicians (253 physicians, 167 nurse practitioners/physician assistants [NP/PAs]) with patient panels in an integrated health system in 59 Midwestern communities serving rural and urban areas in Minnesota, Wisconsin, and Iowa. These clinicians cared for 419,581 patients through 110 care teams, with varying numbers of physicians and NP/PAs.

Relationship of Clinician Care Team Composition and Diabetes Quality Outcomes.

The objective was to determine if a greater proportion of physician full-time equivalent (FTE%) relative to nurse practitioners/physician assistants (NPs/PAs) on care teams was associated with improved individual clinician diabetes quality outcomes. The authors conducted a retrospective cross-sectional study of 420 family medicine clinicians in 110 care teams in a Midwest health system, using administrative data from January 1, 2017 to December 31, 2017. Poisson regression was used to examine the relationship between physician FTE% and the number of patients meeting 5 criteria included in a composite metric for diabetes management (D5).

COVID Care Clinic: A Unique Way for Family Medicine to Care for the Community During the SARS-CoV-2 (COVID-19) Pandemic.

The COVID-19 pandemic has presented new challenges in how Primary Care clinicians care for community patients. Our organization quickly allocated 1 of our community clinic sites into a dedicated COVID Clinic caring for the COVID positive or any patient with COVID like symptoms to minimize contact with the well patients. A prerequisite for all patients to be seen in the COVID Care Clinic was a virtual visit staffed with Advanced Practice Providers that would further determine if the patient needed to seek emergency medical care or be seen in the COVID Clinic.

Ileal Adenocarcinoma with Liver Metastasis in Patient with Crohn's Disease: A 9-Year Survival.

Small bowel adenocarcinoma is a rare but well-known complication of Crohn's disease. The diagnosis of small bowel adenocarcinoma remains difficult since its presentation is highly variable and mimics active or obstructive Crohn's disease. The diagnosis is often delayed and typically detected only at surgery in an advanced stage with a poor prognosis.

Effects of Edoxaban on the Cellular and Protein Phase of Coagulation in Patients with Coronary Artery Disease on Dual Antiplatelet Therapy with Aspirin and Clopidogrel: Results of the EDOX-APT Study.

In patients requiring dual antiplatelet therapy (DAPT) who also have an indication to be treated with oral anticoagulant (OAC) drugs, aspirin withdrawal reduces the risk of bleeding. There is limited data on the pharmacodynamic effects associated with adding a nonvitamin K antagonist OAC on a background of aspirin and a P2Y inhibitor as well as dropping aspirin. Seventy-five patients on DAPT (aspirin plus clopidogrel) were randomized to DAPT plus high-dose edoxaban (60 mg once daily, Group A), DAPT plus low-dose edoxaban (30 mg once daily, Group B), or DAPT only (Group C) for 10 ± 2 days (Phase I).

Glucose oxidase mimicking half-sandwich nickel(II) complexes of coumarin substituted N-heterocyclic carbenes as novel molecular electrocatalysts for ultrasensitive and selective determination of glucose.

Glucose oxidase mimicking nickel-based porous structures with organic anchors are developed as cheap and reliable electrochemical sensors for the quantitative detection of glucose. A series of sterically and electronically modulated, air- and moisture-stable half-sandwich nickel(II) NHC complexes were prepared and characterized. Under the optimized electrocatalytic conditions, the nickel complex immobilized glassy carbon electrodes (GCEs) displayed high sensitivity (0.

Efficacy of oral tranexemic acid in refractory melasma: A clinico-immuno-histopathological study.

Tranexamic acid (TXA), a plasmin inhibitor, is an antifibrinolytic drug widely used to prevent and treat hemorrhage. We evaluated the effects of oral TXA clinically and immunohistopathologically in patients of refractory melasma. To evaluate the efficacy of oral TXA in patients with refractory melasma and correlate histopathological and immunohistochemical changes in pretreatment and post-treatment skin biopsies in patients willing to undergo biopsy.

A Stability-Indicating UPLC Method for the Determination of Potential Impurities and Its Mass by a New QDa Mass Detector in Daclatasvir Drug Used to Treat Hepatitis C Infection.

A stability-indicating ultraperformance liquid chromatographic method has been developed for the quantitative determination of degradation products and process-related impurities of daclatasvir in a pharmaceutical dosage form. Chromatographic separation was achieved on a polar Waters ACQUITY BEH phenyl 100 × 2.1 mm, 1.

Pharmacodynamic Effects of Switching From Ticagrelor to Clopidogrel in Patients With Coronary Artery Disease: Results of the SWAP-4 Study.

Background: Switching between different classes of P2Y inhibitors, including de-escalation from ticagrelor to clopidogrel, commonly occurs in clinical practice. However, the pharmacodynamic profiles of this strategy have been poorly explored.

Methods: This was a prospective, randomized, open-label study conducted in patients on maintenance dosing (MD) of aspirin (81 mg/d) and clopidogrel (75 mg/d).

Realizing High Capacitance and Rate Capability in Polyaniline by Enhancing the Electrochemical Surface Area through Induction of Superhydrophilicity.

Polyaniline (PANI) as a pseudocapacitive material has very high theoretical capacitance of 2000 F g. However, its practical capacitance has been limited by low electrochemical surface area (ESA) and unfavorable wettability toward aqueous electrolytes. This work deals with a strategy wherein the high ESA of PANI has been achieved by the induction of superhydrophilicity together with the alignment of PANI exclusively on the surface of carbon fibers as a thin layer to form a hybrid assembly.

The role of oral anticoagulant therapy in patients with acute coronary syndrome.

Dual antiplatelet therapy (DAPT) with aspirin and a P2Y receptor antagonist represents the current standard of care to prevent atherothrombotic recurrences in patients with acute coronary syndrome (ACS). However, despite the use of DAPT, the recurrence rate of cardiovascular ischemic events still remains high. This persistent risk may be in part attributed to the sustained activation of the coagulation cascade leading to generation of thrombin, which may continue to play a key role in thrombus formation.

Room-Temperature Activation of CO by Dual Defect-Stabilized Nanoscale Hematite (FeO ): Concurrent Role of Fe and O Vacancies.

We demonstrate that synthetically controlled concurrent stabilization of Fe and O vacancy defects on the surface of interbraided nanoscale hematite (FeO ) renders an interesting surface chemistry which can reduce CO to CO at room temperature (RT). Importantly, we realized a highly enhanced output of 410 μmol h g at RT, as compared to that of 10 μmol h g for bulk hematite. It is argued based on the activity degradation under cycling and first principles density functional theory calculations that the excess chemical energy embedded in the defect-stabilized surface is expended in this high-energy conversion process, which leads to progressive filling up of oxygen vacancies.

Hydrogels of polyaniline with graphene oxide for highly sensitive electrochemical determination of lead ions.

Conducting polymers with graphene/graphene oxide hydrogels represent a unique class of electrode materials for sensors and energy storage applications. In this article, we report a facile in situ method for the polymerisation of aniline resulting in the decoration of 1D conducting polyaniline (PANI) nanofibers onto the surface of 2D graphene oxide (GO) nanosheets followed by hydrogel formation at elevated temperature. The synthesized nanomaterial exhibits significant properties for the highly sensitive electrochemical determination as well as removal of environmentally harmful lead (Pb) ions.

Serosurveillance of foot and mouth disease in Karnataka state, India: a 3 years study.

A prospective serological investigation was conducted to determine the prevalence and distribution of foot-and-mouth disease (FMD), as well as to monitor the effectiveness of the FMD control programme (FMD-CP) through vaccination in Karnataka, India. Random serum samples were collected every year between May and August before the start of vaccination in 2011, and subsequently following two phases of vaccination in 2012 and 2013. Infection status (seroprevalence) was inferred by subjecting the sera to indirect r3AB non-structural protein-ELISA, using kits developed by the Project Directorate on FMD, India.