Vitamin D analog calcitriol for breast cancer therapy; an integrated drug discovery approach.

As breast cancer remains leading cause of cancer death globally, it is essential to develop an affordable breast cancer therapy in underdeveloped countries. Drug repurposing offers potential to address gaps in breast cancer treatment. Molecular networking studies were performed for drug repurposing approach by using heterogeneous data.

Autonomic innervation of the human middle ear: an immunohistochemical study.

Purpose: Although there have been numerous studies of autonomic innervation of the middle ear mucosa, and the mechanism of effusion into the middle ear cavity in animals, the autonomic innervation of the human middle ear has not received much attention. The purpose of this study is to show the presence of catecholaminergic nerve fibers in the human middle-ear mucus membrane that may play an important role in the pathogenesis of middle-ear effusion.

Materials And Methods: A total of 126 celloidin-embedded temporal bone sections from the temporal bone bank at the House Ear Institute were used for immunohistochemical study.