Publications by authors named "Nagaoka T"
Purpose: To investigate the impact of foveal glial tissue on the anatomical and functional results after macular hole (MH) surgery.
Methods: This study included 141 consecutive eyes that underwent successful vitrectomy for full-thickness MH between January 2015 and December 2022. The best-corrected visual acuity and the length of outer retinal defects were evaluated preoperatively and at 6 months postoperatively.
Purpose: To document a case of open-globe injury (OGI) caused by a brown bear attack that resulted in a favorable structural and visual outcome.
Observations: A 40-year-old Japanese female was transported by ambulance due to OGI with a choroidal hemorrhage in the right eye, resulting in light perception (LP) visual acuity following a brown bear attack. We pursued a two-stage approach, commencing with primary posterior scleral wound repair and an encircling scleral buckle.
Article Synopsis
- Granulocyte/monocyte adsorption therapy can help treat mild-to-moderate inflammatory bowel disease by removing activated immune cells, and its efficacy was tested using new columns designed for better adsorption.
- In a study with rats suffering from colitis, the new columns led to improved tissue health but didn’t significantly enhance the rate of immune cell adsorption into the blood.
- The therapy was associated with an increase in newly formed B cells that produced higher levels of interleukin-10, suggesting they play a role in reducing inflammation and controlling colitis symptoms.
Article Synopsis
- Omalizumab is effective in reducing severe asthma symptoms, but not all patients experience the same benefits or can use it long-term.
- This study analyzed 82 out of 116 patients treated with omalizumab over two years, assessing factors like asthma control, hospital visits, and medication use.
- The findings indicate that having a certain eosinophil count or specific IgE antibodies can help predict who responds well to treatment, but only the GETE score at two years was associated with continued use of omalizumab beyond that period.
Purpose: To examine the effects of hydrogen water on retinal blood flow (RBF) dysregulation in diabetes, we evaluated changes in RBF in response to flicker stimulation and systemic hyperoxia in diabetic mice.
Methods: Twelve type 2 diabetic mice were divided into a group that received non-hydrogen water (n = 6, control group) and the other that received hydrogen-rich water (0.6-0.
Article Synopsis
- The study aimed to evaluate the effectiveness of anti-VEGF therapy on visual acuity in patients with diabetic macular edema (DME) over two years.
- The research involved analyzing data from 1,780 eyes treated from 2015 to 2019, documenting changes in best-corrected visual acuity (BCVA) and treatment methods.
- Results showed a significant improvement in BCVA, with 73.3% of eyes maintaining good vision, highlighting anti-VEGF therapy as the preferred first-line treatment for DME.
Article Synopsis
- - The SWAN trial aims to evaluate the effectiveness and safety of faricimab for treating diabetic macular edema (DME) by using a flexible "treat-and-extend" dosing strategy adapted to each patient's needs.
- - Participants will receive three initial injections of faricimab every four weeks, and then their dosing schedule will be adjusted based on their DME status, either extending or shortening the intervals.
- - The study will measure changes in visual acuity and other vision-related metrics over two years, with an emphasis on determining appropriate individualized treatment plans for better patient outcomes.
Shorter Drainage Tube to the Pancreatic Stump Reduces Pancreatic Fistula After Distal Pancreatectomy.
Surg Laparosc Endosc Percutan Tech
December 2024
Background: We investigated the relationship between the length of a prophylactic closed-suction drainage tube and clinically relevant postoperative pancreatic fistula (CR-POPF) in distal pancreatectomy (DP).
Materials And Methods: The clinical data of 76 patients who underwent DP using a reinforced stapler for the division of the pancreas at Ehime University Hospital between December 2017 and May 2023 were retrospectively analyzed. Laparoscopic DP was performed in 41 patients (53.
Article Synopsis
- - This study looked at how the shape of the reconstructed portal vein/superior mesenteric vein (PV/SMV) affects long-term nutrition after pancreatic surgery (pancreatoduodenectomy) using a technique called computational fluid dynamics (CFD).
- - Twenty-four patients who had the surgery and were tumor-free for over 9 months were analyzed by creating 3D models from their CT scans taken 3-6 months post-surgery.
- - Results showed that patients with higher pressure or turbulence in blood flow were more likely to experience poorer nutritional recovery within 9 months, demonstrating that CFD can help assess the effectiveness of vein reconstructions.
In this study, we developed and demonstrated a millimeter-wave electric field imaging system using an electro-optic crystal and a highly sensitive polarization measurement technique using a polarization image sensor, which was fabricated using a 0.35-µm standard CMOS process. The polarization image sensor was equipped with differential amplifiers that amplified the difference between the 0° and 90° pixels.
View Article and Find Full Text PDFBackground: Although paramedics can use adrenaline autoinjectors (AAIs) during their duties, the actual conditions of their use and the challenges faced remain unclear. We investigated the actual situation and issues pertaining to creating an environment in which paramedics can operate AAIs more effectively.
Methods: A web-based survey was conducted among paramedics who participated in a web-based training session related to their latest knowledge on food allergies and emergency responses in 2022.
We assessed the short-term effects of switching from intravitreal aflibercept (IVA) to intravitreal faricimab (IVF) on ocular blood flow in patients with treatment-resistant diabetic macular edema (DME). The medical records of 15 patients with DME who had received IVA injection ≥ 3 months before were retrospectively reviewed. The best-corrected visual acuity, central macular thickness (CMT) on optical coherence tomography, and mean blur rate (MBR) of all disc areas on laser speckle flowgraphy were measured before, 1 week after, and 4 weeks after IVA and IVF, respectively.
View Article and Find Full Text PDFPurpose: To evaluate retinal blood flow (RBF) regulation in response to RBF stress in maturity-onset diabetes of the young type 3 (MODY3) pigs.
Study Design: Case-control study.
Methods: MODY3 pigs (diabetes mellitus [DM] group, n = 8) transfected with the human mutant hepatocyte nuclear factor-1⍺ and normal pigs of the same age (normal group, n = 8) were used as subjects.
Article Synopsis
- The study examined factors affecting the difficulty of laparoscopic liver resection (LLR), specifically the distance between the tumor and blood vessels.
- Out of 118 patients studied, 10 (8.5%) required conversion to open surgery, with findings showing that lower platelet counts and closer tumor-vessel proximity (within 10 mm) were significant risk factors.
- The results identified 10 mm as a critical cutoff distance for predicting conversion, making it an important consideration for improving surgical outcomes in LLR.
Article Synopsis
- Recent guidelines recommend against using PAH-targeted therapies in patients with pulmonary hypertension (PH) linked to respiratory diseases, highlighting the need for better assessment of treatment effectiveness.
- The study analyzed 270 patients with precapillary PH, categorizing them into severe and mild cases to evaluate the impact of initial treatments on their prognosis.
- Findings indicated that patients with severe PH and mild ventilatory impairment who received initial treatment showed a significantly better response and prognosis compared to those who did not, while such benefits were not seen in mild PH cases.
Purpose: To report a case of cyclic esotropia successfully treated with prismatic correction.
Observations: A 9-year-old girl presented with intermittent esotropia and diplopia occurring over the previous 4 months. The patient had 30 prism diopters (PD) of esotropia at both distance and near.
Background: No comprehensive analysis of the pulmonary sequelae of coronavirus disease 2019 (COVID-19) in Japan based on respiratory function tests and chest computed tomography (CT) has been reported. We evaluated post-COVID-19 conditions, especially focusing on pulmonary sequelae assessed by pulmonary function tests and chest CT.
Methods: For this prospective cohort study, we enrolled 1069 patients who presented pneumonia at the time of admission in 55 hospitals from February 2020 to September 2021.
Purpose: Auto-antibodies (auto-abs) to type I interferons (IFNs) have been identified in patients with life-threatening coronavirus disease 2019 (COVID-19), suggesting that the presence of auto-abs may be a risk factor for disease severity. We therefore investigated the mechanism underlying COVID-19 exacerbation induced by auto-abs to type I IFNs.
Methods: We evaluated plasma from 123 patients with COVID-19 to measure auto-abs to type I IFNs.
Background: Bronchial thermoplasty (BT) improves clinical outcomes and quality of life for patients with severe asthma and has shown sustained reductions in airway narrowing and air trapping in previous CT studies. However, there is a lack of a comprehensive analysis, including CT evaluation, of clinical outcomes in Japanese patients who have undergone BT for severe asthma. This study aimed to evaluate the impact of BT in Japanese asthma patients, with a focus on the CT metric "WA at Pi10" to assess airway disease.
View Article and Find Full Text PDFPurpose: Post-transplant biliary stricture (PBS) is a common and important complication following orthotopic liver transplantation (LT). This study clarified the incidence of PBS and identified its risk factors.
Methods: We retrospectively reviewed the medical records of 67 patients who underwent living-donor LT (LDLT) at our institute between June 2010 and July 2022 and analyzed their clinical characteristics, prognosis, and risk factors for PBS.
Adjuvant chemotherapy (AC) with S-1 after radical surgery for resectable pancreatic cancer (PC) has shown a significant survival advantage over surgery alone. Consequently, ensuring that patients receive a consistent, uninterrupted S-1 regimen is of paramount importance. This study aimed to investigate whether the C-reactive protein-to-albumin ratio (CAR) could predict S-1 AC completion in PC patients without dropout due to adverse events (AEs).
View Article and Find Full Text PDFAim: The albumin-indocyanine green evaluation (ALICE) score is a useful predictor of post-hepatectomy liver failure (PHLF); however, its usefulness in combination with future liver remnant (FLR), measured by 3-D volumetry, has not been investigated. This study aimed to investigate the relationship between the ALICE of the FLR (ALICE-FLR) score and severe PHLF.
Methods: The clinical data of 215 patients who underwent anatomical hepatectomy for hepatocellular carcinoma without portal vein embolization at two institutes between January 2010 and December 2021 were analyzed retrospectively.
Article Synopsis
- - The study explores the benefits of using the dorsal approach for laparoscopic extended left hemi-hepatectomy, focusing on safely identifying hepatic veins and tumor margins during the procedure.
- - A methodical surgical technique is described, involving the mobilization and dissection of the liver, which allows for safe isolation and division of critical veins associated with tumor removal.
- - There were three successful cases of the procedure performed without any complications or conversions to open surgery, highlighting the effectiveness and safety of the dorsal approach.