molecular docking and antioxidant activity studies of novel -aminophosphonates bearing 6-amino-1,3-dimethyl uracil.

In the present study, a new series of -Aminophosphonates bearing 6-amino-1,3-dimethyluracil was synthesized in good to excellent yields (78-95%) by one-pot, three-component reaction of 6-amino-1,3-dimethyluracil, aromatic aldehydes and diethylphosphite Kabachnik-Fields reaction by using an eco-friendly Eaton's reagent. All the compounds were screened for antioxidant studies by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide (HO) methods. Among the synthesized bioactive molecules, , , , and exhibited promising antioxidant activity compared with the standard drug Ascorbic acid.

Design, synthesis, docking and biological evaluation of chalcones as promising antidiabetic agents.

Diabetes mellitus (DM) is a serious chronic metabolic disorder which occurs due to dysfunction of insulin and therapeutic approaches are poor. It is an under estimation that 387 million people currently suffering globally with diabetic and more than 592 million people may be affected by 2030. It makes an urgent necessity to discover novel drugs to control amplified diabetic populations.

Isolation of flavonoids from the flowers of Rhynchosia beddomei Baker as prominent antimicrobial agents and molecular docking.

Rhynchosia beddomei Baker (R. beddomei) is a viscous hairy under shrub, belongs to the family of Fabaceae and widely distributed in Deccan and Carnatic regions of South India. In the present investigation, four flavonoids such as an isoflavone, 5,7-dihydroxy-4'-methoxyisoflavone (RB-1), a flavonol, quercetin-7-O-methylether (RB-2), two flavone C-glycosides, isovitexin (RB-3) and 5,7,3',4'-tetrahydroxy-6-C-β-d-glucopyranosyl flavone (RB-4) were isolated from the flowers of R.