Publications by authors named "Nafisa Boota"
Importance: Patients with septic shock undergo adrenergic stress, which affects cardiac, immune, inflammatory, and metabolic pathways. β-Blockade may attenuate the adverse effects of catecholamine exposure and has been associated with reduced mortality.
Objectives: To assess the efficacy and safety of landiolol in patients with tachycardia and established septic shock requiring prolonged (>24 hours) vasopressor support.
Article Synopsis
- A 2013 study suggested that using esmolol in patients with septic shock and tachycardia can improve survival rates, though further research on the drug's effects is still needed.
- The STRESS-L trial aims to investigate the effects of landiolol on heart rate and organ failure in 340 patients with septic shock by comparing standard care to care plus a continuous landiolol infusion.
- The trial has received ethical approval and will submit its findings for publication, contributing to clinical practice guidelines surrounding treatment for septic shock.
Background: Clostridium difficile infection (CDI) recurs after initial treatment in approximately one in four patients. A single-centre pilot study suggested that this could be reduced using 'follow-on' rifaximin treatment. We aimed to assess the efficacy of rifaximin treatment in preventing recurrence.
View Article and Find Full Text PDFBackground: The best treatment for fractures of the distal tibia remains controversial. Most of these fractures require surgical fixation, but the outcomes are unpredictable and complications are common.
Objectives: To assess disability, quality of life, complications and resource use in patients treated with intramedullary (IM) nail fixation versus locking plate fixation in the 12 months following a fracture of the distal tibia.