Technetium-99m labeled Ibuprofen: Development and biological evaluation using sterile inflammation induced animal models.

In this study we are presenting the development of technetium-99m (Tc) labeled ibuprofen for the imaging of aseptic inflammation. Tc-Ibuprofen complex was developed by optimizing the radiolabeling conditions such as reaction time, ligand and reducing agent concentration, pH, reaction time and temperature. Following the addition of 600 µg of ibuprofen, 4 µg of stannous chloride as reducing agent and 300 MBq Tc radioactivity; the pH of reaction mixture was adjusted to 11 and allowed to react for 15 min at room temperature.