Publications by authors named "Naeem U Jan"
Article Synopsis
- Plant-derived natural products, like those from Sarcococca saligna, are becoming important in drug discovery for treating various diseases, including cancer.
- This study focused on isolating specific phytochemical constituents (such as Alkaloid-C and Saracodine) and testing their anticancer effects by examining their inhibition of the aromatase enzyme, which is relevant in breast cancer.
- The findings indicated that while the compounds showed some activity in inhibiting aromatase, their bulky structures limited their effectiveness compared to the standard drug exemestane, suggesting that with further modifications, these compounds could develop into potential anticancer agents.
The compounds, sarcovagine-D, alkaloid-C, and holaphylline isolated from were found to possess immunosuppressive activities. These compounds were characterized for inhibition on human T-cells proliferation and IL-2 production. The compounds showed significant immunosuppressive effect on IL-2 production as well as on phytohemagglutinin stimulated T-cell proliferation in a dose dependent manner.
View Article and Find Full Text PDFObjectives: To investigate and compare the hypoglycemic potential of commonly used polyherbal formulation dolabi with pioglitazone in streptozotocin-induced diabetic rats.
Methods: A total of 24 adult male Wistar rats were randomized into diabetic control group, diabetic group receiving dolabi (17.6 mg kg day), diabetic group receiving dolabi (35.
Liraglutide exert favorable effects on most of the diabetes associated cardiovascular (CV) risk factors and this study was designed to further explore the benefits of liraglutide by observing its effect on plasma sialic acid (PSA) in diabetic rats. A total of 30 streptozotocin induced (50 mg/Kg; i.p.
View Article and Find Full Text PDFAlthough management of hyperglycaemia represents one of the principal treatment goals of diabetes therapy, the high incidence of cardiovascular (CV) complications in diabetes also needs effective management. Therefore, the present study was designed to determine and compare the effect of glitazones on serum sialic acid (SSA), a known risk marker for CV disease, along with fasting plasma glucose (FPG), glycohaemoglobin (HbA1-c) and blood lipids, in overweight, previously only diet-treated patients with type 2 diabetes (n=60). The study was conducted for a period of 12 months.
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