Schiff bases targeting an Sw-480 colorectal cell line: synthesis, characterization, ds-DNA binding and anticancer studies.

In present studies, six Schiff bases were prepared, characterized and evaluated for their anti-tumor activity against the colorectal cancer cell line SW-480. The test compounds were characterized by various physico-chemical techniques such as M. P.

Resistance of Lepidopteran Pests to Toxins: Evidence of Field and Laboratory Evolved Resistance and Cross-Resistance, Mode of Resistance Inheritance, Fitness Costs, Mechanisms Involved and Management Options.

() toxins are potential alternatives to synthetic insecticides for the control of lepidopteran pests. However, the evolution of resistance in some insect pest populations is a threat and can reduce the effectiveness of toxins. In this review, we summarize the results of 161 studies from 20 countries reporting field and laboratory-evolved resistance, cross-resistance, and inheritance, mechanisms, and fitness costs of resistance to different toxins.

TAK1-binding protein 2 (TAB2) and TAB3 are redundantly required for TLR-induced cytokine production in macrophages.

Transforming growth factor-β-activated kinase 1 (TAK1) plays a pivotal role in innate and adaptive immunity. TAK1 is essential for the activation of mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-κB pathways downstream of diverse immune receptors, including toll-like receptors (TLRs). Upon stimulation with TLR ligands, TAK1 is activated via recruitment to the lysine 63-linked polyubiquitin chain through TAK1-binding protein 2 (TAB2) and TAB3.

First monitoring of resistance and corresponding mechanisms in the green peach aphid, Myzus persicae (Sulzer), to registered and unregistered insecticides in Saudi Arabia.

Insecticides are widely used as the primary management strategy for controlling Myzus persicae, the devastating pest ravaging various vegetables, fruits, crops, and ornamentals. This study examined the susceptibility of M. persicae field populations to bifenthrin, fosthiazate, acetamiprid, spirotetramat, afidopyropen, and flonicamid while exploring the possible metabolic mechanisms of resistance.

Biological Fitness Cost, Demographic Growth Characteristics, and Resistance Mechanism in Alpha-Cypermethrin-Resistant (Diptera: Muscidae).

L., a pest of animals and humans, has developed resistance to alpha-cypermethrin, a pyrethroid insecticide commonly used to control medically important pests in many countries, including Saudi Arabia. We investigated the mechanism underlying the development of alpha-cypermethrin resistance and life history characteristics of alpha-cypermethrin-susceptible (Alpha-SS) and alpha-cypermethrin-resistant (Alpha-RS) using the age-stage, two-sex life table theory, which is crucial for developing a future rational management strategy and minimizing the negative effects of alpha-cypermethrin on the environment.

Alpha-Cypermethrin Resistance in : Resistance Instability, Realized Heritability, Risk Assessment, and Insecticide Cross-Resistance.

L., the common house fly, is a cosmopolitan carrier of human and livestock disease pathogens. The species exhibits resistance to many insecticides; therefore, effective insecticide resistance management programs are required worldwide.

Realized Heritability, Risk Assessment, and Inheritance Pattern in (Lepidoptera: Noctuidae) Resistant to Dipel ( Kurstaki).

Fabricius is a potential cotton and okra pest in South Asia. The realized heritability, risk assessment, and inheritance mode of Kurstaki (Btk) resistance were determined in the Dipel-selected (DIPEL-SEL) . The DIPEL-SEL strain had a 127.

Toxicities and Cross-Resistance of Imidacloprid, Acetamiprid, Emamectin Benzoate, Spirotetramat, and Indoxacarb in Field Populations of (Diptera: Culicidae).

is a major vector of several pathogens and is capable of breeding in various aquatic habitats. The extensive and injudicious use of synthetic chemicals against the mosquito species has led to the problem of insecticide resistance. To explore this resistance in detail, toxicity bioassays of imidacloprid, acetamiprid, emamectin benzoate, spirotetramat, and indoxacarb were performed on five field populations from Pakistan in addition to a laboratory susceptible strain.

Community composition, bacterial symbionts, antibacterial and antioxidant activities of honeybee-associated fungi.

Background: Fungi associated with insects represent one potentially rich source for the discovery of novel metabolites. However, a comprehensive understanding of the fungal communities of Apis mellifera ligustica remains elusive.

Results: Here, we investigated the phylogenetic diversity and community composition of honeybee-associated fungi using combination of culture-dependent and culture-independent approaches.

Insecticide resistance to insect growth regulators, avermectins, spinosyns and diamides in Culex quinquefasciatus in Saudi Arabia.

Background: Culex quinquefasciatus is not only a biting nuisance but also an important vector of fatal diseases. In Saudi Arabia, management measures to control this mosquito and thereby prevent associated disease transmission have focused on insecticides. Nevertheless, information on the resistance status of C.

Monitoring of field-evolved resistance to flonicamid, neonicotinoid, and conventional insecticides in the Oxycarenus hyalinipennis costa.

Oxycarenus hyalinipennis Costa is a polyphagous insect pest and can develop insecticide resistance. The resistance of O. hyalinipennis to neonicotinoids (clothianidin and dinotefuran), flonicamid, and conventional insecticides; carbamates (methomyl and carbosulfon), organophosphates (chlorpyrifos and malathion), and pyrethroids (cypermethrin and zeta-cypermethrin) was evaluated.

Resistance to insect growth regulators and age-stage, two-sex life table in Musca domestica from different dairy facilities.

Among the vectorial insect pests, the domestic house fly (Musca domestica L., Diptera: Muscidae) is a ubiquitous livestock pest with the ability to develop resistance and adapt to diverse climates. Successful management of the house fly in various locations requires information about its resistance development and life table features.

Risk Assessment of Flonicamid Resistance in Musca domestica (Diptera: Muscidae): Resistance Monitoring, Inheritance, and Cross-Resistance Potential.

Flonicamid is a chordotonal modulator and novel systemic insecticide that has been used frequently for controlling a broad range of insect pests. The risk of flonicamid resistance was assessed through laboratory selection and determining inheritance pattern and cross-resistance potential to five insecticides in house fly, Musca domestica L. Very low to high flonicamid resistance in M.

Fitness cost of imidacloprid resistance in the cotton-staining bug, Dysdercus koenigii.

Dysdercus koenigii, a serious cotton-staining insect pest in many countries, has shown high resistance to imidacloprid, a systemic neonicotinoid insecticide used to control sap-sucking pests. With the aim of creating an effective management strategy, the biological traits of susceptible (SS) and imidacloprid-resistant (Imida-RS) D. koenigii, as well as their reciprocal crosses (CR1 and CR2), were investigated here using a life table established on age, stage, and two-sex patterns.

A Rare Case of Colonic Sarcoidosis Presenting as a Mass.

Introduction: Sarcoidosis is a common multisystem chronic inflammatory disease of an unidentified inciting etiology. The most common initial manifestations of this disease involve the pulmonary system, and involvement of the gastrointestinal tract is rare. Sarcoidosis of the gastrointestinal tract occurs in an oral-anal gradient, with the esophagus and stomach being the most commonly involved sites, while colonic involvement remains extremely rare.

Antibacterial and cytotoxic metabolites of termite-associated Streptomyces sp. BYF63.

Four anthraquinone derivatives, termstrin A, B, C and D (1-4), were isolated and purified from termite-associated Streptomyces sp. BYF63. Their structures were elucidated on the basis of extensive spectroscopic analyses (HR-ESI-MS, 1D and 2D NMR).

Multiple heavy metal tolerance and removal by an earthworm gut fungus Trichoderma brevicompactum QYCD-6.

Fungal bioremediation is a promising approach to remove heavy-metal from contaminated water. Present study examined the ability of an earthworm gut fungus Trichoderma brevicompactum QYCD-6 to tolerate and remove both individual and multi-metals. The minimum inhibitory concentration (MIC) of heavy metals [Cu(II), Cr(VI), Cd(II) and Zn(II)] against the fungus was ranged 150-200 mg L on composite medium, and MIC of Pb(II) was the highest with 1600 mg L on potato dextrose (PD) medium.

Reevaluation of the Efficacy of First Line Regimen for .

Background: is a common cause of gastritis, peptic ulcer disease, and non-ulcer dyspepsia, and is also associated with gastric adenocarcinoma and mucosa associated lymphoid tissue lymphoma. Despite being known about for more than 30 years, finding an effective therapeutic strategy against it remains a challenge.

Aim: There are no US studies evaluating the efficacy of a Levofloxacin based therapy for infection.

Realized heritability, inheritance and cross-resistance patterns in imidacloprid-resistant strain of Dysdercus koenigii (Fabricius) (Hemiptera: Pyrrhocoridae).

Background: Imidacloprid, a neonicotinoid insecticide, is widely sprayed alone or mixed with other insecticides against Dysdercus koenigii, a potential pest of cotton in Pakistan. Recently, resistance to imidacloprid in field populations of D. koenigii has developed because of its overuse.

Field evolved resistance to pyrethroids, neonicotinoids and biopesticides in Dysdercus koenigii (Hemiptera: Pyrrhocoridae) from Punjab, Pakistan.

The red cotton bug, Dysdercus koenigii (Fabricius) is an important emerging economic pest of cotton, Gossypium hirsutum Linnaeus in Pakistan. Insecticides are the primary management tactics to suppress populations of this pest. However, resistance to insecticides evolves due to substantial and repeated applications.

A Rare Presentation of Cryptococcal Meningitis and Cerebellitis in an Asplenic Patient, Seronegative for Human Immunodeficiency Virus (HIV).

BACKGROUND Cryptococcal meningitis in patients who are seronegative for the human immunodeficiency virus (HIV) and in patients who are splenectomized is rare. This report is an unusual case of meningeal and cerebellar infection due to the encapsulated yeast, Cryptococcus neoformans, which has not previously been associated with asplenia. CASE REPORT A 65-year-old HIV-negative patient with a previous splenectomy, presented with a three-day history of fever, vomiting, and headache.

Immunoglobulin A Lambda Multiple Myeloma in a Patient with HIV: An Unusual Cause of Massive Ascites.

Multiple myeloma (MM) is a neoplastic proliferation of plasma cells with overproduction of monoclonal immunoglobulins and infiltration into the bone and other organs. Ascites can develop in patients with lymphoproliferative and solid malignancies involving the peritoneum. However, ascites is unusual in MM and rarely the initial presenting sign or symptom.

Perioperative Care of Patients With Liver Cirrhosis: A Review.

The incidence of cirrhosis is rising, and identification of these patients prior to undergoing any surgical procedure is crucial. The preoperative risk stratification using validated scores, such as Child-Turcotte-Pugh (CTP) and Model for End-Stage Liver Disease, perioperative optimization of hemodynamics and metabolic derangements, and postoperative monitoring to minimize the risk of hepatic decompensation and complications are essential components of medical management. The advanced stage of cirrhosis, emergency surgery, open surgeries, old age, and coexistence of medical comorbidities are main factors influencing the clinical outcome of these patients.

Hyperkalemia Induced Brugada Phenocopy: A Rare ECG Manifestation.

Brugada syndrome (BrS) is an inherited disorder of cardiac ion channels characterized by peculiar ECG findings predisposing individuals to ventricular arrhythmias, syncope, and sudden cardiac death (SCD). Various electrolyte disturbances and ion channels blocking drugs could also provoke BrS ECG findings without genetic BrS. Clinical differentiation and recognition are essential for guiding the legitimate action.