Publications by authors named "Nadya Mothu"
Article Synopsis
- This study examines oxidative stress markers in hemodialysis patients, focusing on regional differences and the impact of vitamin E-coated membranes.
- Baseline measurements of LDL oxidizability were taken from patients at five facilities, followed by a crossover trial comparing vitamin E membranes to standard membranes over several months.
- Results revealed regional variations in LDL oxidizability, but no significant benefits from using vitamin E membranes in improving these oxidative stress markers.
Purpose: Patients with a surgically reduced renal mass are at increased risk for progressive renal failure, which often requires renal replacement therapy or kidney transplantation. We investigated the effects of simvastatin supplementation on uremia enhanced atherosclerosis and vascular calcification in apoE(-/-) (apolipoprotein E deficient) mice (Charles Rivers Laboratories, Wilmington, Massachusetts) with or without superimposed chronic kidney disease.
Materials And Methods: The mice were randomly assigned to 4 groups, including 2 groups with normal renal function (simvastatin vs control in 13 mice) and the other 2 with surgically created chronic kidney disease (simvastatin vs control in 18).
Article Synopsis
- This study investigates the relationship between levels of certain proteins (MMPs, TIMP, TGF-beta1) in the blood and different types of primary glomerulonephritis (GN), which is a kidney disease characterized by fibrosis.
- Researchers measured protein levels in 108 untreated GN patients and compared them to 50 healthy controls, finding distinct plasma patterns for different GN types.
- Significant differences in protein levels were observed, suggesting varying underlying mechanisms influencing kidney fibrosis in these diseases, although no direct correlation was found between protein levels and kidney dysfunction or disease progression.
Objectives: Efforts in recent years have aimed at increasing physicians' awareness of the frequent and harmful consequences of late referral to nephrologists of patients with chronic kidney disease (CKD), shown in repeated concordant studies. We sought to determine whether these efforts have led to improved predialysis care of these patients.
Methods: This study included all 1391 consecutive patients who began maintenance dialysis at Necker Hospital between January 1989 and December 2000.
Background: The novel phosphate binder sevelamer has been shown to prevent the progression of aortic and coronary calcification in uremic patients. Whether it also decreases the progression of atheromatous plaques is unknown. The aim of our study was to examine the effect of sevelamer administration on the development of atherosclerosis and aortic calcification in the uremic apolipoprotein E-deficient mouse as an established model of accelerated atherosclerosis.
View Article and Find Full Text PDFBackground: Whether a general reduction in salt intake reduces or actually enhances cardiovascular mortality in man remains an issue of controversy. Low sodium diets may lead to adverse side effects by stimulating the renin-angiotensin and sympathetic nervous systems. The present study was designed to investigate the effects of low dietary salt on atherosclerotic lesion progression in apolipoprotein E deficient (apoE(-/-)) mice.
View Article and Find Full Text PDFBackground: Inflammation and oxidative stress are established risk factors for atherosclerosis, but whether they contribute to the accelerated atherogenesis associated with chronic kidney disease (CKD) remains to be assessed at the predialysis stage.
Methods: We prospectively examined the relationship between plasma levels of C-reactive protein (CRP), fibrinogen, and advanced oxidation protein products (AOPPs), as selected markers of inflammation and oxidative stress, and incident first occlusive atherosclerotic cardiovascular (CV) events (ASCVEs) in a single-center cohort of 80 uremic predialysis patients without diabetes with a creatinine clearance ranging from 20 to 40 mL/min/1.73 m2 .
Chronic renal failure (CRF) favors the development of atherosclerosis and excessive calcification of atheromatous lesions. CRF was induced in apolipoprotein E knockout (apoE(-/-)) mice to study (1) a possible acceleration of aortic atherosclerosis, (2) the degree and type of vascular calcification, and (3) factors involved in the calcification process. For creating CRF, 8-wk-old apolipoprotein E gene knockout (apoE(-/-)) mice underwent partial kidney ablation.
View Article and Find Full Text PDFBackground: Inflammation and oxidative stress have been incriminated in the pathogenesis of IgA nephropathy (IgAN). The aim of the present study was to assess whether markers reflecting these pathophysiologic processes, namely C-reactive protein (CRP) and advanced oxidation protein products (AOPP), would allow-in conjunction with clinical and histopathologic parameters-to predict disease progression.
Methods: Between 1994 and 1997, 120 adult patients with biopsy-proven IgAN were included in a prospective cohort study, and followed until the end of 2002 or start of dialysis.