Publications by authors named "Nadja Milivojev"
Regeneration of missing body parts can be observed in diverse animal phyla, but it remains unclear to which extent these capacities rely on shared or divergent principles. Research into this question requires detailed knowledge about the involved molecular and cellular principles in suitable reference models. By combining single-cell RNA sequencing and mosaic transgenesis in the marine annelid Platynereis dumerilii, we map cellular profiles and lineage restrictions during posterior regeneration.
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- Brain injury causes neuroinflammation, high extracellular glutamate levels, and mitochondrial dysfunction, all contributing to neuronal death.
- The study analyzed patients with aneurysmal subarachnoid hemorrhage and conducted in vitro experiments to investigate the impact of these mechanisms on neuron health.
- Results indicate that the inhibition of the 2-oxoglutarate dehydrogenase complex by nitric oxide leads to increased extracellular glutamate and subsequent neuronal death, while thiamine can help reverse this toxicity.
Background: Cerebral ischemia and neuroinflammation following aneurysmal subarachnoid hemorrhage (SAH) are major contributors to poor neurological outcome. Our study set out to investigate in an exploratory approach the interaction between NO and energy metabolism following SAH as both hypoxia and inflammation are known to affect nitric oxide (NO) metabolism and NO in turn affects mitochondria.
Methods: In seven patients under continuous multimodality neuromonitoring suffering poor-grade aneurysmal SAH, cerebral metabolism and NO levels (determined as a sum of nitrite plus nitrate) were determined in cerebral microdialysate for 14 days following SAH.