Publications by authors named "Nadiya Gula"
Neuroinflammation is an important risk factor for neurodegenerative disorders like Alzheimer's disease. Nicotinic acetylcholine receptors of α7 subtype (α7 nAChRs) regulate inflammatory processes in various tissues, including the brain. N-stearoylethanolamine (NSE) is a biologically active cell membrane component with anti-inflammatory and membrane-protective properties.
View Article and Find Full Text PDFThis study investigates the protective effect of N-stearoylethanolamine (NSE), a bioactive N-acylethanolamine , on the lipid profile distribution in the pancreas of obesity-induced insulin resistant (IR) rats fed with prolonged high fat diet (58% of fat for 6 months). The phospholipid composition was determined using 2D thin-layer chromatography. The level of individual phospholipids was estimated by measuring inorganic phosphorus content.
View Article and Find Full Text PDFArticle Synopsis
- N-acylethanolamines (NAE), particularly N-stearoylethanolamine (SEA) and N-oleoylethanolamine (OEA), impact the electrical activity of cardiomyocytes in neonatal rat hearts by hyperpolarizing the resting potential and shortening action potential durations.
- OEA is more effective than SEA in reducing currents through voltage-gated Na(+) and L-type Ca(2+) channels, while also influencing K(+) and Cl(-) conductance differently based on the cardiac myocyte type.
- The study suggests that the inhibitory effects of SEA and OEA on excitability may possess cardioprotective properties during conditions like ischemia and infarction, as NAEs increase in such pathological