Genetic polymorphism in is associated with effectiveness and toxicity of pemetrexed in non-small-cell lung cancer.

Patients with advanced non-small-cell lung cancer who are treated with pemetrexed display a wide variation in clinical response and toxicity. In this prospective, multicentre cohort study, we investigated the association with treatment effectiveness and toxicity of 10 polymorphisms in nine candidate genes, covering the folate pathway (), cell transport (), intracellular metabolism () and target enzymes () of pemetrexed. Adjusted for sex, ECOG performance score and disease stage, the association between (rs12995526) and overall survival (HR 1.