Tonic GABAergic control of mouse dentate granule cells during postnatal development.

The dentate gyrus is the main hippocampal input structure receiving strong excitatory cortical afferents via the perforant path. Therefore, inhibition at this 'hippocampal gate' is important, particularly during postnatal development, when the hippocampal network is prone to seizures. The present study describes the development of tonic GABAergic inhibition in mouse dentate gyrus.

Functional maturation of developing interneurons in the molecular layer of mouse dentate gyrus.

The dentate gyrus is the main target for cortical inputs to the hippocampal formation and is particularly strongly controlled by synaptic inhibition. Many GABAergic interneurons migrate from the dentate molecular layer towards their final position in the hilus during the first two postnatal weeks. During this critical period of development we monitored the intrinsic and synaptic properties of developing interneurons in the molecular layer of mouse hippocampal slices.