Publications by authors named "Nadine Tissot"
Background: Cefiderocol is a siderophore cephalosporin antibiotic active against Gram-negative bacteria, including extended-spectrum beta-lactamase and carbapenemase-producing strains. The pharmacokinetics of cefiderocol has been studied in healthy subjects and particularly in phase II and III studies. This retrospective study investigated intravenous cefiderocol population pharmacokinetics in adult patients treated by cefiderocol.
View Article and Find Full Text PDFBackground: Ciprofloxacin is an antibiotic used in osteoarticular infections owing to its very good bone penetration. Very few pharmacokinetic data are available in this population.
Objectives: To investigate oral ciprofloxacin population pharmacokinetics in adult patients treated for osteoarticular infections and propose guidance for more effective dosing.
Article Synopsis
- Cefiderocol and ceftobiprole are advanced antibiotics with variable plasma concentrations that could affect their effectiveness, prompting the need for a reliable method to monitor their levels in patients, especially those critically ill.
- A new, efficient UPLC-MS/MS method was developed for simultaneously measuring both drugs in human plasma, featuring fast analysis times and high accuracy across various metrics.
- The validated method demonstrated robust performance in quantifying drug levels in critically ill patients, aiding in therapeutic drug monitoring and the optimization of antibiotic treatment.
Article Synopsis
- - A new UPLC-MS/MS method was developed for simultaneously measuring nine kinase inhibitors (KIs) and two antiandrogen drugs (AAs) in plasma, aiming to improve therapeutic drug monitoring (TDM) in cancer treatment.
- - The method involves a simple preparation step and quick analysis time (2.8 minutes per run), effectively separating and detecting the drugs with high specificity and sensitivity while meeting all necessary bioanalytical criteria.
- - Calibration curves for the drugs showed excellent linearity over a wide range of concentrations, enabling reliable quantification and facilitating further studies on pharmacokinetics and pharmacodynamics in a clinical setting.
Background: Fluoroquinolones and rifampicin are antibiotics frequently used for the treatment of osteoarticular infections, and their therapeutic drug monitoring is recommended. The aim of this study was to develop and validate a rapid and selective method of simultaneous quantification of levofloxacin, ciprofloxacin, moxifloxacin and rifampicin with short pretreatment and run times in order to be easily used in clinical practice.
Methods: After a simple protein precipitation of plasma samples, the chromatographic separation was performed using an ultra-performance liquid chromatography system coupled with mass tandem spectrometry in a positive ionization mode.
Background: Hydroxychloroquine (HCQ) is approved for the treatment of systemic lupus erythematosus (SLE). Therapeutic drug monitoring of HCQ is necessary to detect nonadherence and to improve treatment efficacy in patients with SLE. Liquid chromatographic-tandem mass spectroscopy and high performance liquid chromatography (HPLC)-fluorescent methods are currently used to measure whole blood concentrations of HCQ and its 2 main metabolites desethylhydroxychloroquine and desethylchloroquine in patients with SLE.
View Article and Find Full Text PDFA sensitive and accurate liquid chromatography method with mass spectrometry detection was developed and validated for the quantification of dabigatran (Pradaxa(®)) and rivaroxaban (Xarelto(®)). (13)C6-dabigatran and (13)C6-rivaroxaban were used as the internal standard. A single-step protein precipitation was used for plasma sample preparation.
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