NOS1-, NOS3-, PIK3CA-, and MAPK-pathways in skin following radiation therapy.

Background: Essential molecular pathways such as the MAPK pathway, NO system, or the influence of PIK3CA as an oncogene are known to regulate fundamental signalling networks. However, few knowledge about their role in the occurrence of wound healing disorders (WHD) following radiation therapy (RT) exists. This study aims to evaluate the expression profiles of specific molecular pathway marker genes.

An Immunohistochemical Study on the Role of Oxidative and Nitrosative Stress in Irradiated Skin.

Background/aim: The effects of ionizing radiation through the generation of free radicals, reactive aldehydes, and other oxidative and nitrosative by-products account for skin injuries as side effects of radiation therapy (RT). This study aims to identify cellular pathways in oxidative and nitrosative stress in irradiated skin using well-established marker proteins in an immunohistochemical analysis.

Materials And Methods: Tissue specimens of 51 patients were obtained during operative access to the neck.