Topology optimization design of the "Beam Shaping Assembly" of an AB-BNCT facility - application to the case of glioblastoma treatment.

This study aims to determine the optimal structure of the Beam Shaping Assembly (BSA) for an AB-BNCT (Accelerator-Based Boron Neutron Capture Therapy) facility. The aim is to maximize the possible depth of treatment for glioblastoma while ensuring that a treatment time constraint is not exceeded. Approach.

Heavy-water-based moderator design for an AB-BNCT unit using a topology optimization algorithm.

. The design of neutron moderators for BNCT treatment units currently relies on parametric approaches, which yield quality results but are ultimately limited by human imagination. Efficient but non-intuitive design solutions may thus be missed out.

On the eptihermal neutron energy limit for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT): Study and impact of new energy limits.

Background And Purpose: Accelerator-Based Boron Neutron Capture Therapy is a radiotherapy based on compact accelerator neutron sources requiring an epithermal neutron field for tumour irradiations. Neutrons of 10 keV are considered as the maximum optimised energy to treat deep-seated tumours. We investigated, by means of Monte Carlo simulations, the epithermal range from 10 eV to 10 keV in order to optimise the maximum epithermal neutron energy as a function of the tumour depth.