Publications by authors named "Nadine Samel"
Cell Death Differ
November 2022
Article Synopsis
- The study investigates how certain processes in B-cell development can lead to adult B-cell progenitor acute lymphoblastic leukemia (BCP-ALL), particularly focusing on Irf4 mice which are more likely to develop this condition as they age.
- It was found that preB-I cells in these mice show poor differentiation but increased proliferation when exposed to IL-7, alongside a decreased ability to stay in the bone marrow due to lower responsiveness to CXCL12.
- The research also suggests that mutations in Jak3, linked to abnormal activation of AID, contribute to the cancer's development, and treating with Ruxolitinib extended the survival of leukemia-affected mice by targeting JAK signaling effects.
