Publications by authors named "Nadine S Zwainy"
Can J Physiol Pharmacol
October 2013
Article Synopsis
- * The research included seven groups of rats to analyze various treatments, with a focus on measuring ET-1 binding affinity and receptor densities in coronary endothelium and cardiomyocytes.
- * Findings showed that while exendin-4 normalized ET-1 receptor binding on the endothelium, aliskiren achieved this effect on cardiomyocytes, suggesting that aliskiren may help reduce blood vessel issues linked to type-1 diabetes.
Exp Diabetes Res
December 2011
Article Synopsis
- This study investigates how long-term suppression of the renin-angiotensin system and incretin mimetic treatments affect GLP-1 receptor binding in heart tissues of type 1 diabetic rats.
- It involves several treatment groups, including normal rats and those treated with insulin, Exendin-4, Aliskiren, or combinations of these therapies.
- Findings indicate diabetes alters GLP-1 binding affinity in different heart tissues, with Exendin-4 combined with Aliskiren normalizing binding in the coronary endothelium, while Exendin-4 alone is most effective in cardiomyocytes.
