Publications by authors named "Nadine Leonie de Boer"
Pre-clinical tumor models of primary brain tumors: Challenges and opportunities.
Biochim Biophys Acta Rev Cancer
January 2021
Article Synopsis
- - Primary brain tumors are diverse cancers that start in the brain's central nervous system, and researchers have created various models to study these tumors for better treatment insights.
- - Many of the potential treatments identified in preclinical studies have not worked well in clinical trials, showing a need for improved animal models to better connect lab findings to real patient outcomes.
- - The review focuses on current glioblastoma modeling strategies and the limitations of these models, stressing the importance of developing new approaches to create effective treatments.
Concomitant intraperitoneal and systemic chemotherapy for extensive peritoneal metastases of colorectal origin: protocol of the multicentre, open-label, phase I, dose-escalation INTERACT trial.
Nadine Leonie de Boer Alexandra R M Brandt-Kerkhof Eva V E Madsen Marjolein Diepeveen Esther van Meerten
BMJ Open
December 2019
Introduction: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) has become standard of care for patients with peritoneal metastases of colorectal origin with a low/moderate abdominal disease load. In case of a peritoneal cancer index (PCI) score >20, CRS-HIPEC is not considered to be beneficial. Patients with a PCI >20 are currently offered palliative systemic chemotherapy.
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