How Safe Are COVID-19 Vaccines in Individuals with Immune-Mediated Inflammatory Diseases? The SUCCEED Study.

We were tasked by Canada's COVID-19 Immunity Task Force to describe severe adverse events (SAEs) associated with emergency department (ED) visits and/or hospitalizations in individuals with immune-mediated inflammatory diseases (IMIDs). At eight Canadian centres, data were collected from adults with rheumatoid arthritis (RA), axial spondyloarthritis (AxS), systemic lupus (SLE), psoriatic arthritis (PsA), and inflammatory bowel disease (IBD). We administered questionnaires, analyzing SAEs experienced within 31 days following SARS-CoV-2 vaccination.

Duration of Postvaccination Neutralizing Antibodies to SARS-CoV-2 and Medication Effects: Results from the Safety and Immunogenicity of COVID-19 Vaccination in Systemic Immune-Mediated Inflammatory Diseases Cohort Study.

Objective: In the face of the ongoing circulation of SARS-CoV-2, the durability of neutralization post-COVID-19 vaccination in immune-mediated inflammatory disease (IMID) is a key issue, as are the effects of medications.

Methods: Adults (n = 112) with inflammatory bowel disease, psoriasis/psoriatic arthritis, rheumatoid arthritis, spondylarthritis, and systemic lupus were recruited from participating Canadian medical centers from 2021 to 2023. We focused on log-transformed neutralization (lentivirus methods) as a continuous outcome, with separate models for wild-type and Omicron strains BA.

When Should I Get My Next COVID-19 Vaccine? Data From the Surveillance of Responses to COVID-19 Vaccines in Systemic Immune-Mediated Inflammatory Diseases (SUCCEED) Study.

Objective: To determine how serologic responses to coronavirus disease 2019 (COVID-19) vaccination and infection in immune-mediated inflammatory disease (IMID) are affected by time since last vaccination and other factors.

Methods: Post-COVID-19 vaccination, data, and dried blood spots or sera were collected from adults with rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, ankylosing spondylitis and spondylarthritis, and psoriasis and psoriatic arthritis. The first sample was collected at enrollment, then at 2 to 4 weeks and 3, 6, and 12 months after the latest vaccine dose.

Prolonged COVID-19 symptom duration in people with systemic autoimmune rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey.

Objective: We investigated prolonged COVID-19 symptom duration, defined as lasting 28 days or longer, among people with systemic autoimmune rheumatic diseases (SARDs).

Methods: We analysed data from the COVID-19 Global Rheumatology Alliance Vaccine Survey (2 April 2021-15 October 2021) to identify people with SARDs reporting test-confirmed COVID-19. Participants reported COVID-19 severity and symptom duration, sociodemographics and clinical characteristics.

Method to geometrically personalize a detailed finite-element model of the spine.

To date, developing geometrically personalized and detailed solid finite-element models (FEMs) of the spine remains a challenge, notably due to multiple articulations and complex geometries. To answer this problem, a methodology based on a free-form deformation technique (kriging) was developed to deform a detailed reference finite-element mesh of the spine (including discs and ligaments) to the patient-specific geometry of 10- and 82-year-old asymptomatic spines. Different kriging configurations were tested: with or without smoothing, and control points on or surrounding the entire mesh.

A new method to include the gravitational forces in a finite element model of the scoliotic spine.

The distribution of stresses in the scoliotic spine is still not well known despite its biomechanical importance in the pathomechanisms and treatment of scoliosis. Gravitational forces are one of the sources of these stresses. Existing finite element models (FEMs), when considering gravity, applied these forces on a geometry acquired from radiographs while the patient was already subjected to gravity, which resulted in a deformed spine different from the actual one.

Biomechanics of the intra-operative lateral decubitus position for the scoliotic spine: effect of the pelvic obliquity.

The intra-operative prone position used for the posterior instrumentation of scoliotic patients has been shown to reduce the spinal deformities prior to instrumentation by 37% on average. However, the effects of the lateral decubitus position used for anterior approaches and minimally invasive techniques have not been investigated. The objectives were to characterize, model and study the biomechanics of this intra-operative posture.

Accessing the influence of repositioning on the pelvis' 3-D orientation in wheelchair users.

This study aimed at evaluating the effects of mechanical repositioning, obtained by the increase in seat-to-back (STB) and system tilt angles, on the position of the pelvis with spinal-cord injured subjects seated in a wheelchair. The noninvasive method used combined magnetic resonance imaging (MRI) images of the whole pelvis obtained in a supine posture and ultrasound images of the pelvic iliac crests obtained in four seating positions. The matching of the two image data sets enabled the location of fourteen pelvic landmarks in the seated positions.