Publications by authors named "Nadina E Rubio-Perez"
Article Synopsis
- - The study investigates how genetic variations in the SLCO1B1 gene can influence the occurrence of adverse events (AEs) in pediatric patients with juvenile idiopathic arthritis (JIA) who are treated with methotrexate (MTX).
- - Researchers analyzed data from 30 JIA patients, finding that 66.7% experienced AEs, and identified that the *1B haplotype was common in this group, significantly increasing the risk of AEs.
- - The findings suggest that patients with the *1B allele may need lower doses of MTX to minimize AEs, and SLCO1B1 genotyping could help tailor treatment strategies to reduce risks during MTX therapy.
Hematogenous spread of Neisseria gonorrhoeae, a sexually transmitted pathogen, results in disseminated gonococcal disease (DGD), also known as arthritis-dermatitis syndrome, due to the development of skin lesions, tenosynovitis, and arthritis. The most frequently affected population is young adults. We describe the case of an adolescent female who acutely developed skin lesions, arthritis, tenosynovitis, and constitutional symptoms.
View Article and Find Full Text PDFMultisystem inflammatory syndrome in children (MIS-C) is an emerging entity during the coronavirus disease 2019 pandemic. Medium- and large-vessel changes are present in MIS-C; however, microcirculatory impairment has not been documented. We report a case of MIS-C in a toddler that presented with persistent fever, gastrointestinal symptoms and rash.
View Article and Find Full Text PDFDevelopment and validation of the CAREGIVERS questionnaire: multi-assessing the impact of juvenile idiopathic arthritis on caregivers.
Pediatr Rheumatol Online J
January 2020
Article Synopsis
- The study focuses on the significant role of primary caregivers for patients with Juvenile Idiopathic Arthritis (JIA), emphasizing that their experiences are influenced by social, emotional, and financial factors that impact the care relationship.
- A mixed methods approach was employed: first, qualitative interviews were conducted with caregivers to create a questionnaire, and then a quantitative phase validated this questionnaire among a larger group.
- The findings highlight nine key themes affecting caregivers, including economic strain and mental health issues, and led to a validated questionnaire that revealed high levels of depression (90%) and anxiety about the future (72%) among the participants.
The incidences of infection with Mycobacterium tuberculosis and Cryptococcus neoformans in immunocompromised patients have increased, but there are few documented cases of their coexistence. We present the case of a 9-year-old female with systemic lupus erythematosus (SLE), treated with prednisone and cyclophosphamide, who was admitted to the emergency department with a 2-week history of fever, headache, malaise, fatigue, and diplopia 3 years after diagnosis. Physical examination showed limitation of abduction of the right eye, Kernig and Brudzinski signs, and hyporeflexia.
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