Evaluation of a new protocol for wheat desensitization in patients with wheat-induced anaphylaxis.

Aim: New approaches such as oral immunotherapy (OIT) may be useful in IgE-mediated anaphylaxis to wheat.

Patients & Methods: 12 patients underwent OIT protocol that comprised of two phases: the first with semolina flour and the second with spaghetti. Total and specific wheat IgE were assayed by ELISA before and after OIT and 18 months later.

Cow's Milk Desensitization in Anaphylactic Patients: A New Personalized-dose Method.

Cow's milk allergy (CMA) is the most frequent food allergy in children and oral immunotherapy (OIT) is a promising approach for treatment of patients. The most challenging cases are anaphylactic with coexisting asthma and proposing safe protocols is crucial especially in high risk groups. Considering that CMA varies among patients, an individualized OIT protocol would be beneficial to achieve a safer and more efficient method of desensitization.

Phenotyping and follow up of forty-seven Iranian patients with common variable immunodeficiency.

Background: Common variable immune deficiency (CVID) is a heterogeneous syndrome with a wide variety of signs and symptoms. This study describes the phenotyping and survival of the CVID patients in the allergy and clinical immunology department of Rasol-E-Akram Hospital of Iran University of Medical Sciences in Tehran.

Method: We retrospectively reviewed hospital files of CVID patients in our department until January 2014.

The effects of vitamin D supplementation on airway functions in mild to moderate persistent asthma.

Background: Vitamin D is hypothesized to have some roles in innate and adaptive immunity, inflammation reduction, and remodeling; therefore, it is supposed to affect the asthma phenotype, severity, and response to inhaled corticosteroid (ICS).

Objective: To explore the synergistic effects of vitamin D supplementation in addition to asthma controllers (ICS or ICS plus long-acting β-agonist) on airway functions.

Methods: A randomized clinical trial was conducted in 130 individuals aged 10 to 50 years who lived in Tehran during a 24-week period.