The prognostic value of [F]FDG PET/CT texture analysis prior to transplantation for unresectable colorectal liver metastases.

Introduction: To determine whether heterogeneity in colorectal liver metastases (CRLM) F fluorodeoxyglucose [F]FDG distribution is predictive of disease-free survival (DFS) and overall survival (OS) following liver transplantation (LT) for unresectable CRLM.

Methods: The preoperative [F]FDG positron emission tomography/computed tomography examinations of all patients in the secondary cancer 1 and 2 studies were retrospectively assessed. Maximum standardized uptake value (SUV), metabolic tumour volume (MTV), and six texture heterogeneity parameters (joint entropy dissimilarity grey level variance size zone variance and zone percentage, and morphological feature convex deficiency) were obtained.

Preoperative 18F-FDG PET/computed tomography predicts survival following resection for colorectal liver metastases.

Objective: The liver is the most frequent metastatic site from colorectal cancer and about 20% of these patients are treated by surgical resection. However, the 5-year disease-free survival (DFS) following resection is only about 25% and 5-year overall survival (OS) about 38%. The aim of the study was to evaluate the ability of metabolic and volumetric measurements from fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) prior to resection for colorectal liver metastases (CLM) to predict survival.