Publications by authors named "Nadia Saraya"
Article Synopsis
- Pathogenic missense variants in the synaptic vesicle protein synaptotagmin-1 (SYT1) lead to a neurodevelopmental disorder with motor delays, intellectual disabilities, and visual impairments due to impaired neurotransmitter release.
- Research on cultured neurons has shown that specific variants in the SYT1 protein hinder exocytosis, causing varying degrees of dysfunction based on the variant's location.
- The study establishes a direct correlation between the exocytic efficiency of SYT1 variants and the severity of developmental impairments, indicating a clear relationship between genetic mutations, neurotransmitter release, and functional outcomes, paving the way for potential therapeutic approaches.
HIV persistence in the brain is a barrier to cure, and potentially contributes to HIV-associated neurocognitive disorders. Whether HIV transcription persists in the brain despite viral suppression with antiretroviral therapy (ART) and is subject to the same blocks to transcription seen in other tissues and blood, is unclear. Here, we quantified the level of HIV transcripts in frontal cortex tissue from virally suppressed or non-virally suppressed people with HIV (PWH).
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