Serological and molecular detection of in ß. thalassemia patients.

is a worldwide opportunistic protozoan causing life-threatening infection in immunocompromised patients, while frequently asymptomatic in immunocompetent individuals. The current study aimed to detect ; serologically and molecularly in ß. thalassemia patients and evaluate the association of infection with some hematological parameters in these patients.

Studying ferroptosis and iron metabolism pre- and post-radiotherapy treatment in breast cancer patients.

Background: Radiotherapy (RT) is an important part of the treatment of many tumors. Radiotherapy causes oxidative damage in all cellular compartments, including lipid membrane, on a random basis. Toxic lipid peroxidation accumulation has only lately been linked to a regulated type of cell death known as ferroptosis.

Levels of Serum Ferritin and Hepcidin in Patients with Uncomplicated Falciparum Malaria in Hodeidah, Yemen: Considerations for Assessing Iron Status.

Understanding the key regulator of iron homeostasis is critical to the improvement of iron supplementation practices in malaria-endemic areas. This study aimed to determine iron indices and hepcidin (HEPC) level in patients infected with compared to apparently healthy, malaria-negative subjects in Hodeidah, Yemen. The study included 70 -infected and 20 malaria-negative adults.

Serum Estrogen and its Soluble Receptor Levels in Egyptian Patients with Chronic Myeloid Leukemia: A Case-Control Study.

Unlabelled: Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder. CML cells contain a BCR-ABL gene, not typically found in normal cells that produce a protein (BCR-ABL) causing CML cells to proliferate. CML occurs in three phases: chronic, accelerated and blast crisis.

Simultaneous Detection of Mycobacterium tuberculosis and Atypical Mycobacteria by DNA-Microarray in Egypt.

Background And Objectives: Immunocompromised patients are a high-risk group for developing mycobacterial infections with either pulmonary and/or extrapulmonary diseases. Low-cost/density DNA-microarray is considered an easy and efficient method for the detection of typical and atypical mycobacterial species.

Materials And Methods: Thirty immunocompromised patients were recruited to provide their clinical specimens (sputum, serum, urine, and lymph node aspirates).

β-Globin Mutations in Egyptian Patients With β-Thalassemia.

β-thalassemia is a common hereditary disorder, particularly in Middle Eastern countries. More than 200 mutations in the β globin gene have been reported; most are point mutations in functionally important regions (HBB; OMIM #141900)). The spectrum of mutations varies significantly between different geographical regions; only a few common mutations of β-globin cause β-thalassemia in each population.

Fungal Infection among Patients with Some Hematopoietic Disorders.

With the increasing number of immune compromised patients suffering from hematological disorders, invasive fungal infections have emerged as a major cause of morbidity and mortality among these patients. This study evaluated the use of conventional blood culture and PCR techniques in the isolation and identification of fungi from patients with different hematopoietic disorders. Ninety blood samples were tested by both techniques, conventional blood culture detected fungal infections in only five (5.