[Chronic granulomatous disease diagnosis: Patients and carriers].

Chronic granulomatous disease (CGD) is a primary immunodeficiency, it has a defect in phagocytosis and its estimated incidence is 1 in 250,000 live births. Recurrent infections and granulomas are the most common clinical manifestations. CGD is caused by a functional defect in one of the subunits of the NADPH oxidase, the patients have mutations in NADPH genes.

[Common variable immunodeficiency. A clinical approach].

Common variable immunodeficiency (CVID) is an immunodeficiency characterized by an impaired ability to produce antibodies associated to multiple clinical phenotypes. The incidence is around 1/50,000 new borns. The age at diagnosis shows 2 peaks, between 1-5 and 16-20 years old.

Intravenous immunoglobulin therapy for hypocomplementemic urticarial vasculitis associated with systemic lupus erythematosus in a child.

Hypocomplementemic urticarial vasculitis is a type of urticarial vasculitis with multisystemic involvement and poor prognosis, sometimes associated with systemic lupus erythematosus. Several therapies have been attempted with no consensus on an effective therapeutic regimen. Intravenous immunoglobulin has been used in severe manifestations of systemic lupus erythematosus and recently in hypocomplementemic urticarial vasculitis.