Publications by authors named "Nadia Milanesio"
Objective: Observational studies suggest that some trace elements and magnesium (Mg) improve glucose metabolism, markers of inflammation, and oxidative stress, but supplementation studies have yielded inconsistent results. Our objective was to evaluate whether a lifestyle intervention trial, aimed at reducing total and saturated fat and increasing fiber intake, can affect also the intake of selenium (Se), zinc (Zn), copper (Cu), chromium (Cr), and Mg.
Methods: Dietary intake of Se, Cr, Zn, Cu, and Mg was evaluated at baseline and at the end of a lifestyle intervention trial performed in 335 dysmetabolic adults.
Article Synopsis
- TCF7L2, specifically the rs7903146 variant, is linked to type 2 diabetes; prior studies revealed it might hinder metabolic improvement from lifestyle changes.
- In a study involving 335 nondiabetic participants, lifestyle interventions effectively improved metabolic measures initially, but benefits largely diminished after four years, especially for those with the TT genotype.
- Ultimately, the presence of the T allele was associated with impaired fasting glucose and a higher risk of diabetes at the four-year mark, even as the effectiveness of the lifestyle intervention waned.
There are conflicting data on the associations between copper and glycemia, plasma lipids, and atherosclerotic diseases. Copper has both pro-oxidant and antioxidant effects. We performed a cross-sectional analysis to investigate the associations between dietary copper intake and metabolic variables and serum high-sensitivity C-reactive protein (hs-CRP) in asymptomatic subjects from a population-based cohort (n = 1197) and between serum copper concentration and markers of oxidative stress, including plasma nitrotyrosine (NT) and total antioxidant status (TAS), hs-CRP, and metabolic variables in a subgroup of men from this cohort (n = 231).
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