Publications by authors named "Nadia Messadecq"
Cell Mol Life Sci
October 2009
Article Synopsis
- Poly(ADP-ribose) polymerase-1 (Parp-1) and SirT1 are essential enzymes that help maintain genome integrity and regulate chromatin in cells.
- Disrupting both Parp-1 and SirT1 genes in mice leads to higher post-natal mortality and telomeric abnormalities, indicating their crucial roles during development.
- The absence of Parp-1 can improve some structural issues in cells lacking SirT1, suggesting these proteins work together in responding to DNA damage and managing specific cellular structures.
