Effects of high-intensity statin therapy on steroid hormones and vitamin D in type 2 diabetic men: A prospective self-controlled study.

The study aimed to assess the effect of high-intensity statin therapy on testicular and adrenal steroids and vitamin D levels in type 2 diabetic men. A prospective study, conducted between March 2021 and July 2022, including 60 men with type 2 diabetes, aged 40-65 years, statin-free, and in whom treatment with high-intensity statin was indicated. The patients had two visits, before and 6 months after a daily intake of 40 mg of atorvastatin.

Salivary Cortisol Measurement Contamination After Oral Hydrocortisone: A Randomized Crossover Trial.

The study aimed to evaluate salivary cortisol (SC) contamination and determine the associated factors in secondary adrenal insufficiency (SAI) patients treated with hydrocortisone (Hc). A randomized crossover trial involved SAI patients. SC was measured before the morning Hc dose, then at one, two, and four hours after.

Metabolic disorders during endogenous Cushing's syndrome: prevalence, associated factors, and outcome after remission.

The prognosis of Cushing's syndrome (CS) is related to a higher cardiovascular morbidity and mortality. This study aimed to determine the prevalence of metabolic disorders in patients with CS, the associated factors, and the rate of remission of these disorders after the remission from CS. It is a retrospective study including 75 cases of CS followed up at the university hospital La Rabta of Tunis from 1987 to 2018.

Professional practices in the management of adrenal insufficiency in two tertiary referral hospitals (Tunis, Tunisia).

Background: Adrenal insufficiency (AI) is a rare and life-threatening disease. Glucocorticoid replacement therapy and patient education are crucial. Few is known about physician practice in this topic.

Predictive factors for recurrence of Cushing's disease after pituitary surgery.

Introduction: The first-line treatment for Cushing's disease (CD) is transsphenoidal excision of the corticotropic adenoma.

Aim: To identify the predictive factors of recurrence of corticotropic adenomas after pituitary surgery.

Methods: This is a retrospective and longitudinal study conducted in 28 patients operated for corticotropic adenoma between 1987 and 2014 and followed up in the department of endocrinology of La Rabta Hospital in Tunis (Tunisia).

[Risk factors for major lower limb amputations in diabetic patients hospitalized for diabetic foot ulcer].

Background: Amputations in diabetes patient lead to high postoperative morbidity and mortality .

Aim: To indentify the risk factors for major lower limb amputations in diabetic patients hospitalized in endocrinology department.

Methods: It was a descriptive retrospective study including diabetic patients hospitalized in the endocrinology department of the Rabta Hospital for management of an infected foot lesion.

Intermittent fasting in adrenal insufficiency patients: a review and guidelines for practice.

Ramadan fasting is a religious duty for adult Muslims. Even though sick people are exempted from fasting, numerous are those who insist on fasting, and seek advice from their physicians. The role of the physician is to support his patient and preserve his health.

Hypopituitarism secondary to a pituitary metastasis in a young woman with an invasive breast carcinoma.

Hypopituitarism secondary to a pituitary metastasis is rare and difficult to diagnose since its symptoms are nonspecific. The presence of visual deficits and nerve palsies should suggest the presence of a pituitary metastasis in a cancer patient.

Assessment of quality of life in adult type 1 diabetic patients.

Introduction: Few studies have examined the quality of life (QOL) of type 1 diabetic patients (T1D) in adulthood and its association with glycemic control.

Aims: To assess the QOL of a Tunisian population of T1D adults and to identify the factors that may influence it.

Methods: It's a cross-sectional study including 100 T1D patients over 18 years of age whose QOL was assessed by the ADDQOL scale.

Salivary cortisol levels during Ramadan fasting in hydrocortisone-treated secondary adrenal insufficiency patients.

Objective: Patients with adrenal insufficiency have difficulties in fasting during the month of Ramadan with an increased risk of complications. Cortisol levels are unknown in these patients. The objective of this study was to assess the daily cortisol profile in hydrocortisone-treated patients with secondary adrenal insufficiency (SAI) and healthy controls during a fasting day.