Publications by authors named "Nadia Kazdar"
Article Synopsis
- Gene expression in meiotic cells in the testis involves high transcription activity and alternative splicing, governed by RNA-binding proteins crucial for fertility.
- A frameshift mutation was found in the RBMXL2 gene of a man with azoospermia, which is linked to meiotic arrest.
- The study confirmed loss of RBMXL2 protein in the patient's testis, indicating that the mutation disrupts spermatogenesis and leads to male infertility through altered gene expression.
Article Synopsis
- The study investigates the real-world effectiveness of Fertistartkit® for ovarian stimulation in women undergoing assisted reproductive technology (ART), based on a cohort of data from French ART centers between 2016 and 2018.
- A total of 1006 cycles from 914 women were analyzed, with an average age of 34.9 years and a median BMI of 22.7 kg/m², revealing an average of 9.5 oocytes retrieved per cycle.
- Findings indicated a 26% ongoing pregnancy rate per initiated cycle, suggesting Fertistartkit® is a viable and effective option for enhancing fertility in diverse infertility cases.
A prospective study on randomized patients was conducted to determine how morphokinetic parameters are altered in embryos grown in sequential versus global culture media. Eleven morphokinetic parameters of 160 single embryos transferred were analyzed by time lapse imaging involving two University-affiliated in vitro fertilization (IVF) centers. We found that the fading of the two pronuclei occurred earlier in global (22.
View Article and Find Full Text PDFIn severe male infertility, in vitro fertilization (IVF) with intra-cytoplasmic sperm injection (ICSI) represents the sole available therapeutic option. However this technique is not always successful in promoting fertilization, as some couples completely and repeatedly fail to obtain any embryo. In many cases, this failure can be attributed to a defective rise in intracellular calcium, which is required to achieve oocyte activation.
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