Publications by authors named "Nadia Hergli"
Background: Congenital generalized lipodystrophy (CGL) is a rare inherited disease characterized by a near-total absence of adipose tissue and is associated with organ system abnormalities and severe metabolic complications. Here, we have analyzed the disease characteristics of the largest CGL cohort from the Middle East and North Africa (MENA) who have not received lipodystrophy-specific treatment.
Methods: CGL was diagnosed clinically by treating physicians through physical assessment and supported by genetic analysis, fat loss patterns, family history, and the presence of parental consanguinity.
Article Synopsis
- Homozygous familial hypercholesterolemia (HoFH) is a rare genetic condition that leads to very high LDL cholesterol levels, increasing the risk of severe heart problems and early death; liver transplants are sometimes done to help manage the condition.
- A study followed nine HoFH patients who underwent liver transplants across various centers in Europe and the Middle East, collecting data on their cholesterol levels and health outcomes for up to 28 years.
- The results showed that liver transplants did not achieve desired LDL cholesterol targets for most patients, with many still needing cholesterol-lowering treatments afterward, indicating that transplants are not a definitive cure for HoFH.
Adjuvants are used to improve vaccine immunogenicity and efficacy by enhancing antigen presentation to antigen-specific immune cells with the aim to confer long-term protection against targeted pathogens. Adjuvants have been used in vaccines for more than 90 years. Combinations of immunostimulatory molecules, such as in the Adjuvant System AS01, have opened the way to the development of new or improved vaccines.
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