Multiple Anesthetic Drug Sensitization in a Hairdresser With Previous Immediate-Type Hypersensitivity to Penicillin: A Case Report.

Risk factors for intraoperative immediate-type hypersensitivity reactions may require allergological evaluation. We report the case of a hairdresser with a positive history of penicillin hypersensitivity and anaphylactic shock during previous general anesthesia, whose in vivo and in vitro allergy tests were positive for neuromuscular blocking agents, opioids, and midazolam. Immediate-type hypersensitivity reactions to antibiotics and professional exposure to hairdressing products might induce simultaneous cross-sensitization to multiple drugs that are commonly used during general anesthesia.

Antibiotic-induced immediate type hypersensitivity is a risk factor for positive allergy skin tests for neuromuscular blocking agents.

Background: Skin tests for neuromuscular blocking agents (NMBAs) are not currently recommended for the general population undergoing general anaesthesia. In a previous study we have reported a high incidence of positive allergy tests for NMBAs in patients with a positive history of non-anaesthetic drug allergy, a larger prospective study being needed to confirm those preliminary results. The objective of this study was to compare the skin tests results for patients with a positive history of antibiotic-induced immediate type hypersensitivity reactions to those of controls without drug allergies.

Elevated serum total IgE alter the diagnostic performance of radio-immune assays for β-lactam specific antibody dosing.

Background: In vivo allergy tests and the detection of drug-specific antibodies are widely used in the diagnosis of β-lactam induced immediate-type hypersensitivity reactions. The diagnostic performance of immunoenzymatic tests for the demonstration of serum-specific IgE (IgEs) antibodies is influenced by total IgE values (IgEt). The aim of this study was to investigate whether the result obtained by radioimmunoassays (RIA) for β-lactams IgEs antibodies is correlated to IgEt.

Epidemiology of self-reported drug-induced immediate-type hypersensitivity reactions in the surgical population: a 5-year single-center survey in a romanian allergo-anaesthesia center.

Aim: Immediate-type hypersensitivity drug reactions are frequently under-reported, epidemiological data being imprecise. The aim of our study was to identify the drugs involved and to describe the clinical characteristics of previous immediate-type hypersensitivity reactions in a large series of Romanian surgical patients, and to establish the concordance between in vivo and in vitro tests.

Methods: Of the 807 surgical patients referred to our outpatient department of allergo-anaesthesia, we retrospectively enrolled 632 patients with previous drug-induced hypersensitivity reactions.