Impact of F1Fo-ATP-synthase dimer assembly factors on mitochondrial function and organismic aging.

In aerobic organisms, mitochondrial FF-ATP-synthase is the major site of ATP production. Beside this fundamental role, the protein complex is involved in shaping and maintenance of cristae. Previous electron microscopic studies identified the dissociation of FF-ATP-synthase dimers and oligomers during organismic aging correlating with a massive remodeling of the mitochondrial inner membrane.