Superior remedy colon cancer HCT-116 cells via new chitosan Schiff base nanocomposites: Synthesis and characterization.

Cancer is a serious worldwide health problem and colon cancer is the major cancer public prevailing form. The innovative pharmaceuticals with great cancer efficacy are metal nanoparticles. Therefore, the present study relies on developing chitosan Schiff base nanocomposites and investigating their antitumor ability against human colon carcinoma (HCT-116 cell line) using the MTT method.

Fabrication and characterization of unique sustain modified chitosan nanoparticles for biomedical applications.

Chitosan (CS) is a biopolymer that offers a wide range in biomedical applications due to its biocompatibility, biodegradability, low toxicity and antimicrobial activity. Syringaldehyde (1) is a naturally occurring organic compound characterized by its use in multiple fields such as pharmaceuticals, food, cosmetics, textiles and biological applications. Herein, development of chitosan derivative with physicochemical and anticancer properties via Schiff base formation from the reaction of chitosan with sustainable eco-friendly syringaldehyde yielded the (CS-1) derivative.

Therapeutic applications of sustainable new chitosan derivatives and its nanocomposites: Fabrication and characterization.

Chitosan (CS) is a biologically active biopolymer used in different medical applications due to its biodegradability, biocompatibility, and nontoxicity. Nanotechnology is an exciting and quick developing field in medical applications. Nanoparticles have shown great potential in the treatment of cancer and inflammation.

New sustainable antimicrobial chitosan hydrogels based on sulfonamides and its nanocomposites: Fabrication and characterization.

Chitosan (Ch), a linear cationic biopolymer, has broad medical applications. In this paper, new sustainable hydrogels (Ch-3, Ch-5, Ch-5) based on chitosan/sulfonamide derivatives 2-chloro-N-(4-sulfamoylphenethyl) acetamide (3) and/or 5-[(4-sulfamoylphenethyl) carbamoyl] isobenzofuran-1,3-dione (5) were prepared. Hydrogels (Ch-3, Ch-5, Ch-5) were loaded (Au, Ag, ZnO) NPs to form its nanocomposites to improve the antimicrobial efficacy of chitosan.

New potential anti-SARS-CoV-2 and anti-cancer therapies of chitosan derivatives and its nanoparticles: Preparation and characterization.

Chitosan (CS) is a biopolymer and has reactive amine/hydroxyl groups facilitated its modifications. The purpose of this study is improvement of (CS) physicochemical properties and its capabilities as antiviral and antitumor through modification with 1-(2-oxoindolin-3-ylidene)thiosemicarbazide (3A) or 1-(5-fluoro-2-oxoindolin-3-ylidene)thiosemicarbazide (3B) via crosslinking of poly(ethylene glycol)diglycidylether (PEGDGE) using microwave-assisted as green technique gives (CS-I) and (CS-II) derivatives. However, (CS) derivatives nanoparticles (CS-I NPs) and (CS-II NPs) are synthesized via ionic gelation technique using sodium tripolyphosphate (TPP).

Synthesis and characterization of polystyrene with embedded silver nanoparticle nanofibers to utilize as antibacterial and wound healing biomaterial.

Herein, silver nanoparticles (Ag) embedded in polystyrene (PS) nanofiber composites have been prepared by an electrospinning technique using N, N-dimethylformamide (DMF) as a solvent and safe reducing agent. Electrospinning of polystyrene (PS) solutions is conducted using different electrospinning parameters such as polymer concentration in the electrospinning solution; solution feed rate, and electrical field strength. Then silver nanoparticles (AgNPs) were embedded into PS nanofibers to obtain an AgNPs-PS nanofiber composite as a powerful, cheap, and nontoxic bioactive material.

Iron Oxide Nanoparticles: Physicochemical Characteristics and Historical Developments to Commercialization for Potential Technological Applications.

Iron oxide nanoparticles (IONPs) have gained increasing attention in various biomedical and industrial sectors due to their physicochemical and magnetic properties. In the biomedical field, IONPs are being developed for enzyme/protein immobilization, magnetofection, cell labeling, DNA detection, and tissue engineering. However, in some established areas, such as magnetic resonance imaging (MRI), magnetic drug targeting (MDT), magnetic fluid hyperthermia (MFH), immunomagnetic separation (IMS), and magnetic particle imaging (MPI), IONPs have crossed from the research bench, received clinical approval, and have been commercialized.

New chitosan derivatives inspired on heterocyclic anhydride of potential bioactive for medical applications.

In the present work new chitosan derivatives inspired heterocyclic anhydride were prepared to improve the biological activities of chitosan via imidization reaction of chitosan (CS) and N-(1,3-dioxoisoindolin-2-yl)-1,3-dioxo-1,3-dihydroiso-benzofuran-5-carboxamide (5) to yield amic acid CS-6 at room temperature and imide CS-8 thermally. However, the reaction between (CS) and anhydride (5) in presence of sodium tripolyphosphate (TPP) or Poly (ethylene glycol) diglycidyl ether (PEGDG) at room temperature yielded CS-6 NPs and CS-7 respectively. The structure of new chitosan derivatives was characterized using morphological and spectroscopic analyses.

Nanoscale Thermosensitive Hydrogel Scaffolds Promote the Chondrogenic Differentiation of Dental Pulp Stem and Progenitor Cells: A Minimally Invasive Approach for Cartilage Regeneration.

Purpose: Several scaffolds and cell sources are being investigated for cartilage regeneration. The aim of the study was to prepare nanocellulose-based thermosensitive injectable hydrogel scaffolds and assess their potential as 3D scaffolds allowing the chondrogenic differentiation of embedded human dental pulp stem and progenitor cells (hDPSCs).

Materials And Methods: The hydrogel-forming solutions were prepared by adding β-glycerophosphate (GP) to chitosan (CS) at different ratios.

Sustainable antimicrobial modified chitosan and its nanoparticles hydrogels: Synthesis and characterization.

The target of the present study is the development of sustainable chitosan and chitosan nanoparticles-based heterocyclic compound hydrogels with antimicrobial properties. Sustainable antimicrobial new modified chitosan hydrogel (CS-3) was synthesized by the reaction of chitosan (CS) with 2-([4-[(1, 3-dioxoisoindolin-2-ylimino) methyl] phenyl] methyleneamino) isoindoline-1, 3-dione (3) via ring opening of cyclic imide moiety in compound (3). However, the modified chitosan nanoparticles hydrogel (CS-3 NPs) were prepared in-situ by an ionotropic gelation technique using sodium tripolyphosphate (TPP) as the cross-linking agent.

Novel hydrazinocurcumin derivative loaded chitosan, ZnO, and au nanoparticles formulations for drug release and cell cytotoxicity.

Synthesis of new hydrazinocurcumin derivative 4-((E)-2-(1-(4-Methoxy benzyl)-6-p-tolylpyridazin-3-yl)-3-((E)-4-hydroxy-3-methoxystyryl)-1H-pyrazol-5-yl)vinyl)-2-methoxyphenol (HCUR) through the reaction of curcumin (CUR) with 1- (4-(2-Methoxybenzyl)-6-p-tolylpyridazin-3-yl)hydrazine(VII). Nanoparticles formulations of (HCUR) loaded chitosan (CS), ZnO, Au, CS-ZnO and CS-Au NPs, via self-assembling process were developed to give CS-HCUR NPs, ZnO-HCUR NPs, Au-HCUR NPs, CS-ZnO-HCUR NPs and CS-Au-HCUR NPs. Chemical structures of (HCUR) and (HCUR) loaded nanoparticles formulations were characterized by UV-Vis, FTIR, Mass Spectrum, Elemental Analysis, HNMR, CNMR, TGA, DSC, SEM and TEM.

Chitosan nanoparticle hydrogel based sebacoyl moiety with remarkable capability for metal ion removal from aqueous systems.

In this present study, a new modified chitosan hydrogel, Cts-SC NPs, was prepared from a one pot reaction of sebacoyl chloride (SC) with chitosan in the presence of 1% v/v glacial acetic acid and 1% w/v sodium tripolyphosphate (TPP) using an ionotropic gelation technique. The modified chitosan hydrogel, Cts-SC NPs, was characterized by FTIR, TEM, XRD, TGA, DSC and SEM. The adsorption efficiency of Cts-SC NPs for metal ions Hg, Ni and Co from aqueous solution was evaluated.

Synthesis of new Schiff bases bearing 1,2,4-triazole, thiazolidine and chloroazetidine moieties and their pharmacological evaluation.

New compounds based on oxindole moiety were synthesized via the reaction of 5-substitued isatins 1a-e with different nucleophiles such as benzidine, 3,3'-dimethoxybenzidine 2a,b and 2,6-diaminopyridine 3 to afford three different classes of bis-Schiff bases 4a-e, 5a-e and 6a-e, respectively. The structures of the new compounds were elucidated on the basis of their FTIR, H NMR, C NMR, GC/MS spectral data and elemental analysis. The in vitro antimicrobial activity of the new compounds was evaluated using a broth dilution technique in terms of minimal inhibitory concentration (MIC) against four bacterial and two fungal pathogens and anticancer activities against HELA cervix.

Design and evaluation of a novel chitosan-based system for colon-specific drug delivery.

Tritrichomonas foetus is a flagellated protozoan parasite that colonizes the feline colon causing colitis and chronic foul smelling diarrhoea. Despite the efficacy of Ronidazole in the treatment of T. foetus, Ronidazole has been reported to cause neurotoxicity in some cats due to rapid absorption in the small intestine.

Consideration of the bioavailability of metal/metalloid species in freshwaters: experiences regarding the implementation of biotic ligand model-based approaches in risk assessment frameworks.

After the scientific development of biotic ligand models (BLMs) in recent decades, these models are now considered suitable for implementation in regulatory risk assessment of metals in freshwater bodies. The BLM approach has been described in many peer-reviewed publications, and the original complex BLMs have been applied in prospective risk assessment reports for metals and metal compounds. BLMs are now also recommended as suitable concepts for the site-specific evaluation of monitoring data in the context of the European Water Framework Directive.

New heterocycle modified chitosan adsorbent for metal ions (II) removal from aqueous systems.

A new hydrogel based on a modified chitosan CS-B was synthesized and evaluated for its metal ion removal from aqueous systems. The CS-B hydrogel was prepared through modification of chitosan with 4-((1, 3-dioxoisoindolin-2-ylimino) methyl) benzaldehyde as a heterocyclic component. The new hydrogel was analyzed by diverse techniques such as FTIR, XRD, TGA, SEM, and swelling tests.

Synthesis and in vitro biological evaluation of new heterocycles based on the indole moiety.

New compounds based on the indole moiety were synthesized via the reaction of indole-3-carbinal 1 with different nucleophiles such as 6-aryl-[4-(2-methoxybenzyl)pyridazin-3-yl] hydrazones 2a-c, benzidine, 3,3'-dimethoxybenzidine 4a,b and 2,6-diaminopyridine 6 to afford hydrazine derivatives 3a-c and three different classes of bis-Schiff bases. The structures of the new compounds were elucidated on the basis of their FTIR, (1)H NMR, (13)C NMR spectral data, GC/MS and elemental analysis. The antimicrobial activity of the new compounds was evaluated using a broth dilution technique in terms of minimal inhibitory concentration (MIC) against four pathogenic bacteria and two pathogenic fungi strains.

New pyrano[2,3-c]pyridazine derivatives with antimicrobial activity synthesized using piperidine as the organocatalyst.

A simple and efficient method for the synthesis of highly diverse pyrano[2,3-c]pyridazines was achieved by a one pot multicomponent reaction using piperidine as the organocatalyst. The synthesis of a series of heterocyclic derivatives with varying functionality (e.g.

New hydrogels based on modified chitosan as metal biosorbent agents.

In this study, two new green biodegradable hydrogels (A1, A2) based on modified chitosan by dialdehydes were prepared via reaction of chitosan with [4,4'-diformyl-α-ω-diphenoxy-ethane or 4,4'-diformyl-2,2'-dimethoxy-α-ω-diphenoxy-ethane] under different reaction conditions. Characterization techniques were applied to the prepared hydrogels as FTIR, TGA, SEM, and X-ray. The efficiency of adsorption of Cu (II), Co (II), Zn (II), Hg (II) and Pb (II) ions from aqueous solution under different pH values were investigated.

Substance-related environmental monitoring strategies regarding soil, groundwater and surface water - an overview.

Substance-related monitoring is an essential tool within environmental risk assessment processes. The soundness of policy decisions including risk management measures is often directly related to the reliability of the environmental monitoring programs. In addition, monitoring programs are required for identifying new and less-investigated pollutants of concern in different environmental media.

Microwave-assisted synthesis of antimicrobial agents based on pyridazine moiety.

An efficient and simple microwave assisted synthesis of sulfonamide derivatives incorporating the pyridazine moiety has been developed. These sulfonamides were used for the preparation of new heterocyclic compounds via reaction with different reagents using a microwave irradiation technique. The structures of the newly synthesized compounds were confirmed on the basis of FTIR, (1)H and (13)C-NMR, mass spectral techniques and elemental analyses.

Fixed-bed column studies on a modified chitosan hydrogel for detoxification of aqueous solutions from copper (II).

A new efficient, low cost chitosan based biosorbent was successfully prepared and employed for the biosorption of copper ions from an aqueous solution using a fixed bed column. Pyromellitic dianhydride crosslinked chitosan as the new adsorbent was characterized by SEM, FTIR spectroscopy, X-ray diffraction, thermogravimetric analysis and solid state (13)C NMR analysis. Scanning electron microscopy coupled with an X-ray energy dispersed analysis for the copper-equilibrated biomass confirmed the presence of Cu(II) ions on the surface of the hydrogel.

Synthesis of a new class of antimicrobial agents incorporating the indolin-2-one moiety.

New furanone derivatives incorporating the indolin-2-one moiety 3 were prepared via the Perkin reaction of isatins 1 with aroylpropionic acids 2 under conventional conditions or microwave irradiation. A series of functionally heterocyclic derivatives (e.g.

New hydrogels based on symmetrical aromatic anhydrides: Synthesis, characterization and metal ion adsorption evaluation.

Unsatisfactory mechanical properties, poor heat resistance, dissolution in acidic media and high swelling ratios limit using chitosan as an adsorbent in industry. In this study, we used dianhydride derivatives famous for their exceptional mechanical and thermal characteristics and low water absorption. In this study, pyromellitic dianhydride (PMDA), benzophenone-3,3',4,4'-tetracarboxylic dianhydride (BTDA), 4,4'-oxydiphthalic dianhydride (ODPA) and 4,4'-(hexafluoroisopropylidene)diphthalic dianhydride (FDA) were utilised as crosslinking agents.

Antiproliferative effects of metal complexes of new isatin hydrazones against HCT116, MCF7 and HELA tumour cell lines.

New hydrazone ligands (HL) derived from 5-substituted isatins and 1-(4-(2-methoxybenzyl)-6-arylpyridazin-3-yl)hydrazines and its complexes with Co(II) and Cu(II) were synthesized. The new hydrazones and their complexes were characterized by means of elemental, spectral analyses and magnetic studies. Primary cytotoxicity evaluation of HL 5a and the new complexes showed that these complexes could act as anticancer agents since they reduced the growth of samples of human tumour cell lines (HCT116((Colon)), MCF7((Breast)) and HELA((Cervix))) to ≤18.