Publications by authors named "Nadia F Ismail"
Gold nanoparticles mediate suppression of angiogenesis and breast cancer growth via MMP-9/NF-κB/mTOR and PD-L1/PD-1 signaling: integrative in vitro validation and network pharmacology insights.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Gold nanoparticles (AuNPs) have emerged as promising candidates for cancer therapy due to their unique physicochemical properties and biocompatibility. In this study, we investigate the synthesis, characterization, and therapeutic potential of AuNPs in breast cancer treatment. Further, it establishes a comprehensive understanding of the mechanisms by which AuNPs suppress angiogenesis and breast cancer growth, identifying novel targets and signaling nodes contributing to the anti-tumor effects of AuNPs.
View Article and Find Full Text PDFImpact of Vitamin D deficiency on immunological and metabolic responses in women with recurrent pregnancy loss: focus on VDBP/HLA-G1/CTLA-4/ENTPD1/adenosine-fetal-maternal conflict crosstalk.
BMC Pregnancy Childbirth
October 2024
Article Synopsis
- Recurrent pregnancy loss (RPL) is defined as two or more consecutive miscarriages and may be influenced by immune system and genetic factors, particularly the Vitamin D Binding Protein (VDBP).
- The study involved 198 women with a history of multiple miscarriages, focusing on the role of Vitamin D levels and its impact on immune function, using various laboratory techniques to analyze these relationships.
- Results indicated that low Vitamin D is linked to reduced natural killer (NK) cell activity and altered protein levels (like VDBP and HLA-G1), suggesting that Vitamin D deficiency could disrupt adenosine metabolism, contributing to reproductive complications.
Recent advances in nanotechnology have offered novel ways to combat cancer. By utilizing the reducing capabilities of Lactobacillus acidophilus, silver nanoparticles (AgNPs) are synthesized. The anti-cancer properties of AgNPs have been demonstrated in previous studies against several cancer cell lines; it has been hypothesized that these compounds might inhibit AMPK/mTOR signalling and BCL-2 expression.
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