Single and combined effects of photodynamic therapy and antibiotics to inactivate Staphylococcus aureus on skin.

In this study, the effect of antimicrobial photodynamic therapy (aPDT) and aPDT combined with antibiotics to inactivate Staphylococcus aureus in vitro and ex vivo was compared. The tetracationic porphyrin 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin tetra-iodide (Tetra-Py-Me) was used to inactivate S. aureus in phosphate buffer solution (PBS) (in vitro) and in pork skin artificially contaminated with S.