Tumor-Draining Lymph Secretome En Route to the Regional Lymph Node in Breast Cancer Metastasis.

Background: During metastasis, tumor cells metastasize from primary tumors to distant organs via the circulatory and the lymphatic systems. There is a plethora of information about metastasis through the circulatory system, however not much information is available about the tumor cells dissemination through the lymphatic system or the lymphatic microenvironment that aids in this process in breast cancer metastasis.

Purpose: The study designed to examine the tumor-derived secretome in lymph before reaching the draining lymph nodes.