Evaluation of the anti-proliferative activity of 2-oxo-pyridine and 1'-spiro-pyridine derivatives as a new class of EGFR and VEGFR-2 inhibitors with apoptotic inducers.

Developing new agents for cancer treatment remains a top priority because it is one of the deadliest worldwide. A new series of 2-oxo-pyridine and 1'-spiro-pyridine derivatives were designed and synthesized based on an -(ethyl benzoate) moiety. The structure of the designed derivatives was confirmed by different spectroscopic techniques (FT-IR and NMR) and elemental analysis and then evaluated as antiproliferative against HepG-2 and Caco-2 cell lines compared with Doxorubicin.