Publications by authors named "Nadezhda Yanakieva-Georgieva"
Introduction: The nephro-protective effects of angiotensin II receptor blockers (ARBs) are widely known; however, there are few reports of long-term effects focusing on the renal vessels. We studied afferent arteriolar changes induced by the long-term administration of an ARB.
Materials And Methods: Thirty-two 6-week-old male Zucker fatty rats (ZFRs) were divided into following four groups (n = 8 in each): ZFR Group and ZFR+High Group fed a standard or high-salt diet, respectively; ZFR+ARB Group and ZFR+High+ARB Group fed a standard or high-salt diet with ARB (Olmesartan, 5 mg/kg/day), respectively.
Article Synopsis
- The study investigates the effects of angiotensin II receptor blockers (ARB) on diabetic nephropathy, focusing on their role in reducing inflammation in the kidneys during early stages of the disease.
- Local ARB treatment in diabetic rats resulted in lower levels of protein in urine and blood urea nitrogen, along with decreased infiltration of inflammatory cells in the kidneys.
- The findings suggest that blocking the renin-angiotensin system locally could be an effective strategy for preventing the worsening of diabetic nephropathy.